60677-40-9

Basic information

• Product Name: 4-amino-3-bromo-5-chloroacetophenone
• Synonyms: 4-amino-3-bromo-5-chloroacetophenone
• CAS NO: 60677-40-9
• Molecular Weight: 248.507
• Mol File: 60677-40-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-amino-3-bromo-5-chloroacetophenone(CAS DataBase Reference)
• NIST Chemistry Reference: 4-amino-3-bromo-5-chloroacetophenone(60677-40-9)
• EPA Substance Registry System: 4-amino-3-bromo-5-chloroacetophenone(60677-40-9)

Safety Data

• Hazardous Substances Data: 60677-40-9(Hazardous Substances Data)

Upstream product

• 99-92-3 p-aminobenzophenone 
• 6953-83-9 1-(4-amino-3-chlorophenyl)ethan-1-one 

Downstream Products

• 37153-52-9 bromoclenbuterol 
• 1263282-93-4 2-(3-bromo-5-chlorophenyl)acetaldehyde 
• 60677-42-1 3-bromo-5-chloro-4-methoxycarbonylamino-α-bromoacetophenone 
• 60677-41-0 3-bromo-5-chloro-4-methoxycarbonylaminoacetophenone 

Relevant articles and documents

Phenylethanolamine β receptor agonist synthetic method

The invention discloses a phenylethanolamine β receptor agonist synthetic method, comprises the following steps: S1: the 4 - amino acetophenone dissolved in an organic solvent, with the electrophilic reagent occurs on the benzene ring substituted halogenated reaction, generating [...] intermediate; [...] intermediates in organic solvent or in water, under the catalysis of the metal catalyst with the cyanide reagent undergo nucleophilic substitution reaction, generating phenyl ketone intermediate; S2: phenyl ketone intermediates in organic solvent, with the copper bromide generating carbonyl α bromo reaction to produce α - bromoacetophenone intermediates; S3: α - bromoacetophenone intermediates in organic solvent with tert-butyl amine or isopropylamine reaction intermediates acetophenone amines; S4: acetophenone amine intermediates in organic solvent, with the reduction hydrogenation reagent react to generate the phenylethanolamine β receptor agonists; synthetic method of this invention a simple and highly efficient and cheap and easy to obtain, atom utilization is high, the synthetic product chemical purity is greater than 99%, to meet the detection requirements of the food safety.