60680-39-9Relevant academic research and scientific papers
Synthesis of new 2-acetyl and 2-benzoyl quinoxaline 1,4-di-N-oxide derivatives as anti-Mycobacterium tuberculosis agents
Jaso, Andres,Zarranz, Belen,Aldana, Ignacio,Monge, Antonio
, p. 791 - 800 (2003)
A series of 2-acetyl and 2-benzoyl-6(7)-substituted quinoxaline 1,4-di-N-oxide derivatives were synthesized and evaluated for in vitro antituberculosis activity. The results show that 2-acetyl-3-methylquinoxaline 1,4-di-N-oxide derivatives with chlorine,
New quinoxaline 1,4-di-N-oxides. Part 1: Hypoxia-selective cytotoxins and anticancer agents derived from quinoxaline 1,4-di-N-oxides
Amin, Kamelia M.,Ismail, Magda M.F.,Noaman, Eman,Soliman, Dalia H.,Ammar, Yousry A.
, p. 6917 - 6923 (2007/10/03)
Hypoxic cells which are common feature of solid tumors are resistant to both anticancer drugs and radiation therapy. Thus, the identification of drugs with the selective toxicity toward hypoxic cells is an important target in anticancer chemotherapy. Tira
