60682-95-3

Usage

Uses

Used in Organic Synthesis:
1-(diethoxyphosphorylMethylsulfonyl)-4-Methylbenzene is used as a reactive intermediate in organic synthesis for the creation of various complex organic molecules. Its unique structure and reactivity allow for the formation of new chemical bonds and the synthesis of specialized compounds.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 1-(diethoxyphosphorylMethylsulfonyl)-4-Methylbenzene is used as a building block for the development of new drugs. Its complex structure and reactivity can be leveraged to create novel pharmaceutical agents with specific therapeutic properties.
Used in Materials Science:
1-(diethoxyphosphorylMethylsulfonyl)-4-Methylbenzene is utilized in materials science for the development of new materials with unique properties. Its incorporation into polymers or other materials can result in enhanced characteristics such as improved stability, reactivity, or specific interactions with other molecules.
Safety Considerations:
Due to the potential toxicity and reactivity of 1-(diethoxyphosphorylMethylsulfonyl)-4-Methylbenzene, it is crucial to conduct thorough safety assessments and implement appropriate handling procedures in all applications. Further research is necessary to understand the full scope of its hazards and to develop strategies for safe use in various industries.

Upstream product

• 814-49-3 diethyl chlorophosphate 
• 3185-99-7 Methyl p-tolyl sulfone 
• 34125-84-3 chloromethyl p-tolyl sulfide 

Downstream Products

• 177213-26-2 (E)-1-((3-(benzyloxy)prop-1-en-1-yl)sulfonyl)-4-methylbenzene 
• 177213-44-4 (Z)-3-benzyloxy-1-(4-tolylsulfonyl)propene 
• 16212-08-1 1-methyl-4-[(E)-2-phenylethenesulfonyl]benzene 
• 852948-56-2 diethyl [3,5-dimethyl-4-N-(3'-iso-propyl-4'-methoxymethoxyphenylamino)phenoxy]methylphosphonate 
• 852949-92-9 diethyl [4-(3'-dimethylamino-4'-methoxymethoxybenzyl)-3,5-dimethylphenoxy]methylphosphonate 
• 852947-40-1 diethyl [3,5-dimethyl-4-(4'-methoxymethoxy-3'-iso-propylbenzyl)phenoxy]methylphosphonate 
• 108620-66-2 p-Tolyl-o-nitrostyrylsulfon 
• 1380035-50-6 C₂₁H₂₁NO₂S 
• 107772-61-2 C₁₄H₁₃NO₂S 
• 876293-46-8 C₁₃H₁₂O₃S 
• 1380035-49-3 C₂₀H₂₀O₂S₂ 
• 35836-45-4 2-[(E)-2-(Toluene-4-sulfonyl)-vinyl]-thiophene 
• 1380035-31-3 C₁₃H₁₆O₂S 
• 1380035-51-7 C₂₀H₂₄O₂S 

Relevant academic research and scientific papers

SYNTHETIC PROCESS FOR PREPARATION OF MACROCYCLIC C1-KETO ANALOGS OF HALICHONDRIN B AND INTERMEDIATES USEFUL THEREIN INCLUDING INTERMEDIATES CONTAINING -SO2-(P-TOLYL) GROUPS

Disclosed is a compound of formula 1, or a pharmaceutically acceptable salt thereof, where R1, R2, R3, R4, R5, R6, R7, R7', R8, R9, R10, R11, R12 and R13 are as disclosed herein. Also, disclosed is a process for the preparation of the compound of formula 1, or a pharmaceutically acceptable salt thereof, and intermediates used therein. The compound of formula 1 can be used in the preparation of halichondrin analogs, such as Eribulin; and a process for its preparation from the compound of formula 1 is also disclosed.

Early introduction of the amino group to the C27-C35 building block of Eribulin

A new synthetic strategy towards the C27-C35 subunit of Eribulin (1) has been devised to include a protected 1,2-amino alcohol at C34-C35. Early introduction of the C35 amino group in the synthesis of 1 increases the efficiency of the route. This new approach can be accomplished on a multi-gram scale and allows for the successful synthesis of Eribulin.

Rh2(II)-catalyzed nitro-group migration reactions: Selective synthesis of 3-nitroindoles from β-nitro styryl azides

Rhodium carboxylate complexes (1 mol %) catalyze the migration of electron-withdrawing groups to selectively produce 3-substituted indoles from β-substituted styryl azides. The relative order of migratorial aptitude for this transformation is ester ? amide H sulfonyl benzoyl ? nitro.

(Alkoxyallyl)sulfones as enal β-anion equivalents. Synthesis of 5-substituted 2(5H)-furanones

2(5H)-Furanones 14 may be prepared in a four-step sequence starting from (alkoxyallyl)sulfone 10 and aldehydes.

1-Benzyloxy-3-(p-tolylsulfonyl)propene as an acrolein β-anion equivalent. Synthesis of 4-substituted 2-butenolides

Lithiation of 1-benzyloxy-3-(p-tolylsulfonyl)propene 6 and reaction with aldehydes give alcohols 7. Sequential hydrolysis-cyclization, oxidation and DBU-mediated elimination of dine elements of p-TolSO2H gives 4-substituted 2-butenolides 10 in good overall yield.