60692-36-6Relevant academic research and scientific papers
Metal-free aza-Claisen type ring expansion of vinyl aziridines: An expeditious synthesis of seven membered N-heterocycles
Singh, Deepak,Ha, Hyun-Joon
supporting information, p. 3093 - 3097 (2019/03/26)
A metal-free approach for the synthesis of 7-membered aza-heterocycles has been developed by the intermolecular [5 + 2] cycloaddition of non-activated vinylaziridines and alkynes. This method has a broad substrate scope under mild reaction conditions to a
Nucleophilic trifluoromethylation of aziridinyl ketones: A convenient access to fluorinated aziridinyl alcohols
Mlostoń, Grzegorz,Obijalska, Emilia,Zi?bacz, Paulina,Matyszewski, Krzysztof,Urbaniak, Katarzyna,Linden, Anthony,Heimgartner, Heinz
, p. 192 - 197 (2013/11/19)
A convenient synthesis of α-(aziridin-2-yl)-α-(trifluoromethyl) alcohols starting with ethyl aziridine-2-carboxylates is reported. Grignard reaction with the corresponding Weinreb amides led to aziridin-2-yl ketones, and subsequent treatment with Ruppert-Prakash reagent gave the trimethylsilylated target compounds as mixtures of diastereoisomers, which were desilylated with TBAF. In the case of ethyl 1-((S)-1-phenylethyl)aziridine-2-carboxylate, (S,S)- and (S,R)-aziridin-2-yl ketones were obtained, separated chromatographically and transformed into the desired enantiomerically pure α-trifluoromethylated alcohols.
Synthesis of 1,2,5- and 1,2,3,5-substituted pyrroles from substituted aziridines via Ag(I)-catalyzed intramolecular cyclization
Kim, Jun Hee,Lee, Sang Bin,Lee, Won Koo,Yoon, Doo-Ha,Ha, Hyun-Joon
, p. 3553 - 3558 (2011/06/11)
An efficient synthesis of 1,2,5- and 1,2,3,5-substituted pyrroles has been achieved from the sequential reactions including a ring-opening of 1-(aziridin-2-yl)propargylic alcohols by various nucleophiles under mild condition followed by an intramolecular
