60694-66-8Relevant academic research and scientific papers
Diarylketone ketoreductase screen and synthesis demonstration to access mglu2 receptor potentiators
Magnus, Nicholas A.,Coffey, D. Scott,Debaillie, Amy C.,Jones, Chauncey D.,Kaluzna, Iwona A.,Kambourakis, Spiros,Pu, Yangwei J.,Wang, Lin,Wepsiec, James P.
, p. 1377 - 1381 (2011)
This communication describes proof of concept for an enantioselective enzyme-based synthesis of diarylmethanol (S)-1 to access mGlu2 receptor potentiators. A ketoreductase (KRED) screen was applied to benzophenone 8 to afford chiral diarylmethanol (S)-9,
