60695-93-4

Upstream product

• 942-06-3 4,5-dichlorophthalic anhydride 
• 145303-69-1 4,5-dichloro-2-methoxycarbonyl benzoic acid 

Downstream Products

• 1256593-25-5 methyl 4,5-dichloro-2-formylbenzoate 
• 880347-55-7 2-(benzo[1,2,5]thiadiazole-4-sulfonylamino)-4,5-dichlorobenzoic acid 
• 1297599-49-5 2-(benzo[1,2,5]thiadiazole-4-sulfonylamino)-4,5-dichlorobenzoyl chloride 
• 880347-54-6 2-(benzo[1,2,5]thiadiazole-4-sulfonylamino)-4,5-dichloro-benzoic acid methyl ester 
• 844647-17-2 2-amino-4,5-dichloro-benzoic acid methyl ester 
• 1256593-29-9 (Z)-methyl 4,5-dichloro-2-(2-cyanovinyl)benzoate 
• 1256593-27-7 (E)-methyl 4,5-dichloro-2-(2-cyanovinyl)benzoate 

Relevant academic research and scientific papers

Protecting-group-free synthesis of a dual CCK1/CCK2 receptor antagonist

In our pursuit of an efficient, protecting-group-free synthesis of the dual CCK1/CCK2 receptor antagonist 1, we have developed chemoselective conditions for sulfonamide formation reaction in pure water and a PhNMe2 mediated carboxamide formatio

MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF

The present application relates to aryl- and heteroaryl-fused decahydropyrroloazepine, octahydrooxepinopyrrole, octahydropyrrolothiazepine dioxide, decahydrocyclohepta[c]pyrrole, and octahydrocyclohepta[c]pyrrole derivatives of formula (I), wherein R1,R2, R3, R4, R5, A, Y1, Y2, and Y3 are as defined in the specification. The present application also relates to compositions comprising such compounds, processes for making such compounds, and methods of treating disease conditions using such compounds and compositions, and methods for identifying such compounds.

Anthranilic sulfonamide CCK1/CCK2 dual receptor antagonists II: Tuning of receptor selectivity and in vivo efficacy

In the previous article we demonstrated how certain CCK2R-selective anthranilic amides could be structurally modified to afford high-affinity, selective CCK1R activity. We now describe our efforts at modulating and optimizing the CCK1R and CCK2R affinitie

SULFONAMIDE COMPOUNDS

Certain sulfonamide compounds are dual CCK1/CCK2 inhibitors useful in the treatment of CCK1/CCK2 mediated diseases.

Quinoxaline compounds

Certain amidophenyl-sulfonylamino-quinoxaline compounds are CCK2 modulators useful in the treatment of CCK2 mediated diseases.

Condensed pyridazinyl guanidines, their production and use

Pyridazinyl guanidines of the formula: wherein ring A is a benzene ring or a nitrogen-containing 6-membered aromatic ring, each of which may be substituted; and R1is an aromatic ring group which may be substituted, or a salt thereof, which have activity for inhibiting Na-H exchange and are useful as a prophylactic/therapeutic agent for ischemic cardiovascular diseases such as myocardial infarction and arrythmia.