844647-17-2

Basic information

• Product Name: 2-aMino-4,5-dichloro-benzoic acid Methyl ester
• Synonyms: 2-aMino-4,5-dichloro-benzoic acid Methyl ester;BENZOIC ACID, 2-AMINO-4,5-DICHLORO-, METHYL ESTER
• CAS NO: 844647-17-2
• Molecular Formula: C₈H₇Cl₂NO₂
• Molecular Weight: 220.05268
• EINECS: -0
• Mol File: 844647-17-2.mol
• Article Data: 11

Chemical Properties

• Melting Point: 119-121 °C(Solv: methanol (67-56-1))
• Boiling Point: 328.4±37.0 °C(Predicted)
• Appearance: /
• Density: 1.433±0.06 g/cm3(Predicted)
• PKA: 0.90±0.10(Predicted)
• CAS DataBase Reference: 2-aMino-4,5-dichloro-benzoic acid Methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-aMino-4,5-dichloro-benzoic acid Methyl ester(844647-17-2)
• EPA Substance Registry System: 2-aMino-4,5-dichloro-benzoic acid Methyl ester(844647-17-2)

Safety Data

• Hazardous Substances Data: 844647-17-2(Hazardous Substances Data)

Usage

General Description

2-Amino-4,5-dichloro-benzoic acid methyl ester is a chemical compound with the molecular formula C9H8Cl2NO2. It is a methyl ester derivative of 2-amino-4,5-dichlorobenzoic acid, and is commonly used in organic synthesis and pharmaceutical research. 2-aMino-4,5-dichloro-benzoic acid Methyl ester is a white to slightly off-white solid with a melting point of around 200-202°C. It is a potentially hazardous substance and should be handled with care, as prolonged or repeated exposure may cause skin irritation, eye irritation, and respiratory tract irritation. This chemical is primarily utilized as a building block for the synthesis of various pharmaceutical and agrochemical compounds, and is commonly found in research laboratories and chemical manufacturing facilities.

Upstream product

• 20776-61-8 2-amino-4,5-dichloro-benzoic acid 
• 18107-18-1 diazomethyl-trimethyl-silane 
• 67-56-1 methanol 
• 15997-89-4 4,5-dichlorophthalimide 
• 145303-69-1 4,5-dichloro-2-methoxycarbonyl benzoic acid 
• 942-06-3 4,5-dichlorophthalic anhydride 
• 60695-93-4 methyl 4,5-dichloro-2-(chlorocarbonyl)benzoate 
• 5900-58-3 2-amino-4-chloro-benzoic acid methyl ester 
• 844647-19-4 C₉H₅Cl₂N₃O₃ 
• 40928-13-0 4-chloroisatoic anhydride 
• 77423-12-2 6,7-dichloro-1,2-dihydro-3,1-benzoxazine-2,4-dione 

Downstream Products

• 880347-54-6 2-(benzo[1,2,5]thiadiazole-4-sulfonylamino)-4,5-dichloro-benzoic acid methyl ester 
• 880347-55-7 2-(benzo[1,2,5]thiadiazole-4-sulfonylamino)-4,5-dichlorobenzoic acid 
• 1297599-49-5 2-(benzo[1,2,5]thiadiazole-4-sulfonylamino)-4,5-dichlorobenzoyl chloride 
• 20776-61-8 2-amino-4,5-dichloro-benzoic acid 
• 844647-21-8 4,5-dichloro-2-(quinoxaline-5-sulfonylamino)benzoic acid methyl ester 
• 869550-60-7 methyl 2-acetamido-4,5-dichlorobenzoate 

Relevant articles and documents

NOVEL HISTONE METHYLTRANSFERASE INHIBITORS

The present invention relates to novel compounds of formula (I) as defined herein. The compounds are inhibitors of histone methyltransferases of the seven-beta-strand family, in particular of KMT9.

Hofmann-type rearrangement of imides by in situ generation of imide-hypervalent iodines(III) from iodoarenes

The Hofmann-type rearrangement of aromatic and aliphatic imides using a hypervalent iodine(III) reagent generated in situ from PhI, m-CPBA, and TsOH·H2O proceeded in the presence of a base in alcohol to provide anthranilic acid derivatives and amino acid derivatives in high yields, respectively. This reaction proceeds through a tandem reaction via alcoholysis followed by a Hofmann rearrangement promoted by the formation of an imide-λ3-iodane intermediate.

Anthranilic sulfonamide CCK1/CCK2 dual receptor antagonists II: Tuning of receptor selectivity and in vivo efficacy

In the previous article we demonstrated how certain CCK2R-selective anthranilic amides could be structurally modified to afford high-affinity, selective CCK1R activity. We now describe our efforts at modulating and optimizing the CCK1R and CCK2R affinitie