606965-96-2

Upstream product

• 15356-62-4 L-menthoxyacetyl chloride 
• 606965-95-1 2-((1R,2S,5R)-2-Isopropyl-5-methyl-cyclohexyloxy)-N-(4-nitro-benzyl)-acetamide 
• 7409-30-5 p-nitrobenzylamine 

Downstream Products

• 622849-18-7 3-hydroxy-4-[(4-{[2-(2-isopropyl-5-methyl-cyclohexyloxy)-acetylamino]-methyl}-phenylamino)-methyl]-8-methoxy-1,9-dimethyl-11-oxo-11H-dibenzo[b,e][1,4]dioxepine-6-carboxylic acid 

Relevant academic research and scientific papers

Synthesis and biological evaluation of menthol-based derivatives as inhibitors of plasminogen activator inhibitor-1 (PAI-1)

Compound 1 was identified by high throughput screening as a novel PAI-1 inhibitor. Optimization of the B and C-segments of 1 resulted in a series of structurally simplified compounds with improved potency. The synthesis and SAR data of these compounds are presented here.