606970-66-5Relevant academic research and scientific papers
Sterically demanding, bioxazoline-derived N-heterocyclic carbene ligands with restricted flexibility for catalysis
Altenhoff, Gereon,Goddard, Richard,Lehmann, Christian W.,Glorius, Frank
, p. 15195 - 15201 (2007/10/03)
A unique family of N-heterocyclic carbenes derived from bioxazolines (IBiox) suitable for application in transition-metal catalysis is described. The ligands are electron rich, sterically demanding, and have restricted flexibility. Their usefulness has been demonstrated in the Suzuki-Miyaura cross-coupling of sterically hindered aryl chlorides and boronic acids. For the first time, tetraortho-substituted biaryls with methyl and larger ortho-substituents have been synthesized from aryl chlorides using the Suzuki-Miyaura method.
