60708-66-9Relevant academic research and scientific papers
Design and development of novel Mycobacterium tuberculosis l-alanine dehydrogenase inhibitors
Saxena, Shalini,Samala, Ganesh,Sridevi, Jonnalagadda Padma,Devi, Parthiban Brindha,Yogeeswari, Perumal,Sriram, Dharmarajan
, p. 401 - 414 (2015)
In the present study, we used crystal structure of MTB L-AlaDH protein complex with N6-methyl adenosine for structure based virtual screening of in house database to identify new small molecule inhibitors for MTB-L-AlaDH. Two molecules identified as better leads and were modified synthetically to obtain thirty novel analogues belonging to 2-iminothiazolidine-4-ones and 4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxamides. Among the screened compounds four (4n, 4o, 12 and 14) emerged as potent inhibitors displaying IC50 values ranging from 0.58 ± 0.02 to 1.74 ± 0.03 μM against MTB-L-AlaDH and were non-cytotoxic at 50 μM. Some of these synthesized compounds also exhibited good activity against nutrient starved dormant MTB cells. The most potent inhibitors were found to stabilize the protein which was confirmed biophysically through differential scanning fluorimetry.
Study of Hydantoin. III . Mass Spectrometric Behaviour in the Electron Impact of 2-Imino-4-thiazolidinone Derivatives
Kwon, Byoung M.,Park, Jeen Woo
, p. 1725 - 1727 (2007/10/02)
The mass spectral decomposition modes of a series of 2-imino-4-thiazolidinone derivatives are reported and discussed.The fragmentation patterns and mechanisms postulated have been confirmed by the analysis of the MIKE spectra and using DADI technique and
