60712-47-2

Usage

Uses

Used in Pharmaceutical Industry:
2-([(4-METHYLPHENYL)SULFONYL]AMINO)-2-PHENYLACETIC ACID is used as a synthetic intermediate for the development of various pharmaceuticals, leveraging its potential pharmacological properties to contribute to the creation of new medications.
Used in Agrochemical Industry:
In the agrochemical sector, 2-([(4-METHYLPHENYL)SULFONYL]AMINO)-2-PHENYLACETIC ACID is utilized as a synthetic intermediate, playing a crucial role in the formulation of agrochemical products that can enhance crop protection and yield.
Used in Research and Development:
2-([(4-METHYLPHENYL)SULFONYL]AMINO)-2-PHENYLACETIC ACID is employed as a research tool to explore its antiproliferative and anti-inflammatory effects, aiding scientists in understanding its potential applications in medicinal chemistry and drug discovery.
Used in Chemical Compound Preparation:
2-([(4-METHYLPHENYL)SULFONYL]AMINO)-2-PHENYLACETIC ACID is also used in the preparation of other chemical entities, highlighting its versatility and importance in the synthesis of a wide range of molecules for various applications across different industries.

InChI:InChI=1/C15H15NO4S/c1-11-7-9-13(10-8-11)21(19,20)16-14(15(17)18)12-5-3-2-4-6-12/h2-10,14,16H,1H3,(H,17,18)/p-1/t14-/m1/s1

Upstream product

• 875-74-1 (R)-phenylglycine 
• 98-59-9 p-toluenesulfonyl chloride 

Downstream Products

• 63406-97-3 N-(p-tolylsulfonyl)-D-α-phenylglycine chloride 
• 68180-11-0 N-toluenesulfonyl-N-methyl-D-phenylglycine 
• 1019853-27-0 (R)-N-methoxy-N-methyl-2-phenyl-2-(tosylamino)acetamide 
• 1333260-15-3 (3aS,8bS)-1,2,3,3a,4,8b-hexahydrocyclopenta[b]indole salt with N-tosyl-(R)-phenylglycine 
• 1333260-13-1 (3aR,8bR)-1,2,3,3a,4,8b-hexahydrocyclopenta[b]indole salt with N-tosyl-(R)-phenylglycine 
• 118917-59-2 (R)-N-(2-hydroxy-1-phenylethyl)-4-methyl-S-methylenebenzenesulfinamide 
• 1393751-27-3 4-methyl-N-(((2R,5R)-5-phenyl-4-tosylmorpholin-2-yl)methyl)benzenesulfonamide 
• 1393751-28-4 4-methyl-N-(((2S,5R)-5-phenyl-4-tosylmorpholin-2-yl)methyl)benzenesulfonamide 
• 1393751-17-1 (R)-N-allyl-N-(2-hydroxy-1-phenylethyl)-4-methylbenzenesulfonamide 
• 863016-87-9 (R)-N₁-(1-methyl-2-oxo-2-phenylethyl)-4-methyl-1-benzenesulfonamide 

Relevant academic research and scientific papers

Design, Synthesis, and Testing of Potent, Selective Hepsin Inhibitors via Application of an Automated Closed-Loop Optimization Platform

Hepsin is a membrane-anchored serine protease whose role in hepatocyte growth factor (HGF) signaling and epithelial integrity makes it a target of therapeutic interest in carcinogenesis and metastasis. Using an integrated design, synthesis, and screening platform, we were able to rapidly develop potent and selective inhibitors of hepsin. In progressing from the initial hit 7 to compound 53, the IC50 value against hepsin was improved from ～1 μM to 22 nM, and the selectivity over urokinase-type plasminogen activator (uPA) was increased from 30-fold to >6000-fold. Subsequent in vitro ADMET profiling and cellular studies confirmed that the leading compounds are useful tools for interrogating the role of hepsin in breast tumorigenesis.

Gold-Catalyzed Aminoalkenylation of β-Amino-1,n-Diynols to Cycloalkyl-, Piperidinyl- and Pyranyl-Fused Pyrroles

A synthetic method to prepare cycloalkyl-, piperidinyl- and pyranyl-fused pyrroles efficiently by gold(I)-catalyzed dehydrative aminoalkenylation of β-amino-1,n-diynols under mild conditions at room temperature is described.

Stereoselective synthesis of morpholines via copper-promoted oxyamination of alkenes

A new copper(II) 2-ethylhexanoate-promoted addition of an alcohol and an amine across an alkene (oxyamination) is reported. The alcohol addition is intramolecular, while coupling with the amine occurs intermolecularly. Several 2-aminomethyl morpholines we

Amino acid-derived hydroxamic acids as chiral ligands in the vanadium catalysed epoxidation

New sulfonamide-derived hydroxamic acids 7-11 have been developed as chiral ligands for the V-catalysed asymmetric epoxidation, showing high reactivity at subzero temperatures and moderate to good enantioselectivity. The strong accelerating effect exhibited by the ligands of this type can be attributed to the sulfonamide functionality. A range of cinnamyl type allylic alcohols were epoxidised with up to 74% ee. The Royal Society of Chemistry 2005.

N- and 2-Substituted N-(Phenylsulfonyl)glycines as Inhibitors of Rat Lens Aldose Reductase

A variety of N-(phenylsulfonyl)-N-phenylglycines 5, N-(phenylsulfonyl)-2-phenylglycines 6, and N-(phenylsulfonyl)anthranilic acids 7 were prepared as analogues of the N-(phenylsulfonyl)glycine 1 aldose reductase inhibitors.In the rat lens assay, several derivatives of 5 display greater inhibitory activity than the corresponding glycines 1, suggesting that N-phenyl substitution enhances affinity for aldose reductase.Enzyme kinetic evaluations of the 4-benzoylamino analogues of 5 and 1 demonstrate that these compounds produce inhibition by the same mechanism.However, the significant differences in relative inhibitory potencies between compounds of series 5 and 1 may indicate that these compounds do not interact with the inhibitor binding site in precisely the same manner.Evaluation of the individual enantiomers of series 6 reveals that the S isomers are substantially more active than the corresponding R isomers.Also, with the exception of the naphthalene analogue 6n, the S stereoisomers of this series display greater inhibitory potencies than the glycines 1.The anthranilates 7 generally are less active than the glycines 1, demonstrating that direct incorporation of an aromatic ring in the glycine side chain may result in a decrease in affinity for aldose reductase.