863016-87-9

Upstream product

• 927209-13-0 N-(2-hydroxy-1,2-diphenylethyl)-4-methylbenzenesulfonamide 
• 121758-19-8 4-methyl-N-((1R,2R)-2-{[(4-methylphenyl)sulfonyl]amino}-1,2-diphenylethyl)benzenesulfonamide 
• 60712-47-2 (R)-2-((4-methylphenyl)sulfonamido)-2-phenylacetic acid 
• 875-74-1 (R)-phenylglycine 
• 98-59-9 p-toluenesulfonyl chloride 
• 1019853-27-0 (R)-N-methoxy-N-methyl-2-phenyl-2-(tosylamino)acetamide 
• 100-58-3 phenylmagnesium bromide 

Downstream Products

• 1019853-29-2 1(S),2(R),5(R)-diphenyltetrahydro-1aH-oxireno[2,3-c]pyrrol-3-yl (4-methylphenyl) sulfone 

Relevant academic research and scientific papers

An efficient [3+2] annulation for the asymmetric synthesis of densely-functionalized pyrrolidinones and γ-butenolides

Disclosed here is a new [3+2] annulation of siloxy alkynes that provides robust access to highly enantioenriched, densely-substituted pyrrolidinones and γ-butenolides, whose direct synthesis remains challenging. This process also represents a rare asymmetric synthesis of enantrioenriched molecules from siloxy alkynes.

Gold-Catalyzed Aminoalkenylation of β-Amino-1,n-Diynols to Cycloalkyl-, Piperidinyl- and Pyranyl-Fused Pyrroles

A synthetic method to prepare cycloalkyl-, piperidinyl- and pyranyl-fused pyrroles efficiently by gold(I)-catalyzed dehydrative aminoalkenylation of β-amino-1,n-diynols under mild conditions at room temperature is described.

Epoxy-annulations by reactions of α-amido ketones with vinyl sulfonium salts. Reagent versus substrate control and kinetic resolution

(Chemical Equation Presented) Diphenyl vinyl sulfonium salt and chiral amido-ketones undergo highly diastereoselective epoxy-annulation reactions in good yield. The use of a chiral vinyl sulfonium salt dominates the stereochemical outcome of the annulatio

First osmium-catalysed ketamination of alkenes

Conditions for a first oxidative conversion of alkenes into 2-amino ketones are described, which yield racemic products within a direct oxidation pathway and 2-amino ketones with up to 99% enantiomeric excess from the corresponding enantiopure amino alcohols. The Royal Society of Chemistry 2005.