60715-04-0Relevant articles and documents
EDDA-catalyzed rapid synthetic routes for biologically interesting polycycles bearing citrans and chalcones: the first total synthesis of sumadain A
Wang, Xue,Lee, Yong Rok
, p. 10125 - 10133 (2009)
An efficient and concise synthetic route for biologically interesting polycycles bearing citran and chalcone nuclei was developed starting from a variety of trihydroxybenzenes with substituents on the ring. The key strategies involved an ethylenediamine diacetate-catalyzed cyclization by a domino aldol-type/electrocyclization/H-shift/hetero Diels-Alder reaction of trihydroxybenzenes and citral or trans,trans-farnesal. This methodology was applied successfully to the synthesis of three natural products, desbenzylidenerubramin, rubraine, sumadain A, and their unnatural derivatives.
Neuroregenerative Potential of Prenyl- And Pyranochalcones: A Structure-Activity Study
Aigner, Ludwig,Bieler, Lara,Couillard-Despres, Sebastien,Priglinger, Eleni,Riepl, Herbert M.,Urmann, Corinna
, p. 2675 - 2682 (2021/10/12)
Loss of neuronal tissue is a hallmark of age-related neurodegenerative diseases. Since adult neurogenesis has been confirmed in the human brain, great interest has arisen in substances stimulating the endogenous neuronal regeneration mechanism based on ad
Chromane-like cyclic prenylflavonoids for the medical intervention in neurological disorders
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Page/Page column 38-39, (2017/01/23)
The present invention relates to certain chromane-like cyclic prenylflavonoids, in particular the compounds of formulae (I), (II) and (III) as described and defined herein, for use in the treatment or prevention of a neurological disorder, as well as their use in promoting neuronal differentiation, neurite outgrowth and neuroprotection.
Concise total synthesis of biologically interesting pyranochalcone natural products: Citrunobin, boesenbergin A, boesenbergin B, xanthohumol C, and glabrachromene
Yong, Rok Lee,Xia, Likai
, p. 3240 - 3246 (2008/09/16)
New and efficient synthetic approaches to the biologically interesting natural products citrunobin, boesenbergins A and B, xanthohumol C, and glabrachromene are described. The key strategies involve ethylenediamine diacetate catalyzed benzopyran formation