60717-51-3

Basic information

• Product Name: DIMETHYL-PIPERIDIN-2-YLMETHYL-AMINE
• Synonyms: DIMETHYL-PIPERIDIN-2-YLMETHYL-AMINE;2-(DIMETHYLAMINOMETHYL)PIPERIDINE;UKRORGSYN-BB BBV-075946;N-(2-Piperidylmethyl)dimethylamine;N-(Piperidin-2-ylmethyl)dimethylamine;N,N-Dimethyl-1-(piperidin-2-yl)methanamine;N,N-Dimethyl-2-piperidinemethylamine;NSC 74470
• CAS NO: 60717-51-3
• Molecular Formula: C₈H₁₈N₂
• Molecular Weight: 142.24
• Mol File: 60717-51-3.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 178℃
• Flash Point: 51℃
• Appearance: /
• Density: 0.868
• Vapor Pressure: 0.995mmHg at 25°C
• Refractive Index: 1.45
• CAS DataBase Reference: DIMETHYL-PIPERIDIN-2-YLMETHYL-AMINE(CAS DataBase Reference)
• NIST Chemistry Reference: DIMETHYL-PIPERIDIN-2-YLMETHYL-AMINE(60717-51-3)
• EPA Substance Registry System: DIMETHYL-PIPERIDIN-2-YLMETHYL-AMINE(60717-51-3)

Safety Data

• Hazardous Substances Data: 60717-51-3(Hazardous Substances Data)

Usage

General Description

DIMETHYL-PIPERIDIN-2-YLMETHYL-AMINE is a chemical compound with the molecular formula C10H22N2. It is a derivative of piperidine and is commonly used as a precursor in the synthesis of pharmaceuticals and other organic compounds. DIMETHYL-PIPERIDIN-2-YLMETHYL-AMINE is a tertiary amine, meaning it contains three alkyl groups bonded to the nitrogen atom. It is also known for its use as a catalyst in various organic reactions due to its basic properties. DIMETHYL-PIPERIDIN-2-YLMETHYL-AMINE is a colorless liquid with a strong odor and should be handled with caution due to its potential for skin and eye irritation.

InChI:InChI=1/C8H18N2/c1-10(2)7-8-5-3-4-6-9-8/h8-9H,3-7H2,1-2H3

Upstream product

• 130606-00-7 piperidine-2-carbonyl chloride 
• 4043-87-2 pipecolic Acid 
• 130497-14-2 (+/-)-[(N-ethoxycarbonyl)piperidine]-2-carboxylic acid 
• 130497-29-9 Piperidine-2-carboxylic acid dimethylamide 

Downstream Products

• 1125598-12-0 methyl 4-{2-[1-benzhydryl-5-chloro-2-(2-{[(2-{2-[(dimethylamino)methyl]-1-piperidinyl}ethyl)sulfonyl]amino}ethyl)-1H-indol-3-yl]ethoxy}benzoate 
• 1189164-41-7 C₃₃H₄₈N₄O₂ 
• 112282-25-4 1-(3,4-dichlorophenyl) acetyl-2-dimethylaminomethyl piperidine hydrochloride 
• 130497-36-8 1-<(3,4-dichlorophenyl)acetyl>-N,N-dimethyl-2-piperidinemethanamine 

Relevant articles and documents

(2S)-1-(arylacetyl)-2-(aminomethyl)piperidine derivatives: Novel, highly selective κ opioid analgesics

This paper describes the synthesis and structure-activity relationships as κ opioid analgesics of a novel class of 1-(arylacetyl)-2-(aminomethyl)piperidine derivatives (8). The active conformation of the pharmacophore, with a torsional angle (N1C2C7N8) of 60°, was defined with computational studies and 1H NMR. A quantitative structure-activity relationship study of the arylacetic moiety substitution indicated that the presence of an electron-withdrawing and lipophilic substituent in para and/or meta positions is required for good analgesic activity and κ affinity. The lead compounds (2S)-1-[(3,4-dichlorophenyl)acetyl]-2-(pyrrolidin-1-ylmethyl) piperidine hydrochloride (14) and (2S)-1-[[4-(trifluoromethyl)phenyl]acetyl]-2-(pyrrolidin-1- ylmethyl)piperidine hydrochloride (21) are the most κ/μ selective (respectively 6500:1 and 4100:1) and among the most potent (K(i) κ 0.24 and 0.57 nM, respectively) κ ligands identified so far. In the mouse tail flick model of antinociception, compound 14 (ED50 = 0.05 mg/kg sc) was 25 times more potent than morphine and 16 times more potent than the standard κ ligand U-50488.