60721-39-3Relevant academic research and scientific papers
N-(2,2,2-trichloroethylidene)- and N-(1-hydroxy-2,2,2-trichloroethyl) amides in C-amidoalkylation reaction of functionally-substituted aromatic compounds
Aizina,Rozentsweig,Levkovskaya,Rozentsweig,Mirskova
, p. 235 - 238 (2007/10/03)
A reaction with phenol and pyrocatechol of N-(2,2,2-trichloroethylidene)arenesulfonyl-, ethoxycarbonylamides and 1-hydroxy-substituted N-(2,2,2-trichloroethyl)amides of arenesulfonic, carbamic, and acetic acids in the presence of oleum or in sulfuric acid provided the corresponding (1-amido-2,2,2-trichloroethyl)-substituted phenols. N-(2,2,2-Trichloroethylidene)-4-chlorobenzenesulfonamide reacted with salicylamide in the presence of oleum to afford 3-aminocarbonyl-4-[2,2,2-trichloro-1-(4-chlorobenzene-sulfonamido)ethyl]benzene whereas the 1-hydroxy-2,2,2-trichloroethylamides of the acetic, carbamic, and arenesulfonic acids did not enter into such reactions.
SYNTHESIS AND SOME PROPERTIES OF 1,1-DI(ALKOXYCARBONYLAMINO)-2,2-DIHALOGENO- AND 1,1-DI(ALKOXYCARBONYLAMINO)-2,2,2-TRIHALOGENOETHANES
Bal'on, Ya. G.,Smirnov, V. A.
, p. 2249 - 2254 (2007/10/02)
1,1-Di(alkoxycarbonylamino)-2,2,2-trihalogenoethanes were obtained by heating trihalogenoacetaldehydes or their hydrates with urethanes in a ratio of 1:2 in the presence of catalytic amounts of concentrated sulfuric acid.The products were reduced selectively with aluminum amalgam in 90percent alcohol to 1,1-di(alkoxycarbonylamino)-2,2-dihalogenoethanes.Compounds of both types react smoothly with benzene and its homologs in the presence of concentrated sulfuric acid and give 1-alkoxycarbonylamino-1-aryl-2,2-dihalogeno- and 1-alkoxycarbonylamino-1-aryl-2,2,2-trihalogenoethanes respectively.In an alkaline medium the latter are cleaved to aryloxyacetic acid, and with phosphorus pentachloride they form 1-aryl-2,2-dihalogeno- and 1-aryl-2,2,2-trihalogenoethyl isocyanates.
