541-79-7

Usage

Uses

Sedative-hypnotic.

Brand name

Prodorm (Parke-Davis).

InChI:InChI=1/C5H8Cl3NO3/c1-2-12-4(11)9-3(10)5(6,7)8/h3,10H,2H2,1H3,(H,9,11)

Upstream product

• 75-87-6 chloral 
• 51-79-6 urethane 
• 16723-30-1 (2,2,2-trichloro-ethylidene)-carbamic acid ethyl ester 
• 79-01-6 Trichloroethylene 
• 13698-16-3 ethyl N,N-dichlorocarbamate 
• 302-17-0 chloral hydrate 
• 7647-01-0 hydrogenchloride 

Downstream Products

• 67049-75-6 (2,2-dichloro-ethyl)-carbamic acid ethyl ester 
• 75-87-6 chloral 
• 51-79-6 urethane 
• 70123-49-8 (2,2,2-Trichloro-1-p-tolyl-ethyl)-carbamic acid ethyl ester 
• 16723-33-4 1-Anilino-2.2.2-trichlor-ethyl-carbaminsaeureethylester 
• 60721-39-3 (2,2,2-Trichloro-1-phenyl-ethyl)-carbamic acid ethyl ester 

Relevant academic research and scientific papers

Discovery of a dual tubulin polymerization and cell division cycle 20 homologue inhibitor via structural modification on apcin

Apcin is one of the few compounds that have been previously reported as a Cdc20 specific inhibitor, although Cdc20 is a very promising drug target. We reported here the design, synthesis, and biological evaluations of 2,2,2-trichloro-1-aryl carbamate derivatives as Cdc20 inhibitors. Among these derivatives, compound 9f was much more efficient than the positive compound apcin in inhibiting cancer cell growth, but it had approximately the same binding affinity with apcin in SPR assays. It is possible that another mechanism of action might exist. Further evidence demonstrated that compound 9f also inhibited tubulin polymerization, disorganized the microtubule network, and blocked the cell cycle at the M phase with changes in the expression of cyclins. Thus, it induced apoptosis through the activation of caspase-3 and PARP. In addition, compound 9f inhibited cell migration and invasion in a concentration-dependent manner. These results provide guidance for developing the current series as potential new anticancer therapeutics.

Expedient synthesis of perhaloaldehyde N-acyl hemiaminals

Various perhaloaldehyde N-acyl hemiaminals 1 are readily prepared in high yields by condensation of amides 7 with easily available perhaloaldehyde O-ethyl hemiacetals 8 or hydrates 9 in the presence of 5 A molecular sieves.

Synthesis of α-(acylamino)polyhaloalkylphosphoryl compounds by the reaction of trivalent phosphorus chlorides with N-(α-hydroxypolyhaloalkyl)amides

N-(α-Hydroxypolyhaloalkyl)amides react with trivalent phosphorus chlorides to give α-(acylamino)polyhaloalkylphosphoryl compounds via phosphorotropic rearrangement of intermediate phosphites or phosphinites.