60723-28-6

Basic information

• Product Name: N-methyl-N-(4-oxocycloheptyl)benzamide
• CAS NO: 60723-28-6
• Molecular Formula: C₁₅H₁₉NO₂
• Molecular Weight: 245.3169
• Mol File: 60723-28-6.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 415.4°C at 760 mmHg
• Flash Point: 185.2°C
• Density: 1.11g/cm³
• Vapor Pressure: 4.15E-07mmHg at 25°C
• Refractive Index: 1.552
• CAS DataBase Reference: N-methyl-N-(4-oxocycloheptyl)benzamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-methyl-N-(4-oxocycloheptyl)benzamide(60723-28-6)
• EPA Substance Registry System: N-methyl-N-(4-oxocycloheptyl)benzamide(60723-28-6)

Safety Data

• Hazardous Substances Data: 60723-28-6(Hazardous Substances Data)

Upstream product

• 145192-97-8 (S)-N-(1,4-Dioxa-spiro[4.6]undec-8-yl)-benzamide 
• 145192-90-1 N-<(1S)-4-oxocycloheptyl>benzamide 
• 145264-13-7 N-<(1S,4S)-4-hydroxycycloheptyl>benzamide 
• 31510-13-1 N-cycloheptylbenzamide 
• 98-88-4 benzoyl chloride 
• 145192-98-9 N-(S)-1,4-Dioxa-spiro[4.6]undec-8-yl-N-methyl-benzamide 
• 82748-85-4 physoperuvine hydrochloride 

Relevant articles and documents

Catalytic Asymmetrization of meso-3,7-Bis-siloxycycloheptene by Chiral Rhodium(I)-binap Catalyst: the Enantiocontrolled Asymmetric Synthesis of (-)-(S)-Physoperuvine

Catalytic asymmetrization of meso-3,7-bis-tert-butyldimethylsiloxycycloheptene occurs in the presence of a chiral rhodium(I) binap catalyst to give optically active 4-tert-butyldimethylsiloxycycloheptanone in 70percent ee after hydrolytic workup, the (R)-enantiomer of which has been transformed into (-)-(S)-physoperuvine, the major alkaloid of Physalis peruviana.

REVISED STRUCTURE OF PHYSOPERUVINE, AN ALKALOID OF PHYSALIS PERUVIANA ROOTS

The previously reported physoperuvine, an alkaloid isolated from the roots of Physalis peruviana, has been found to be a hydrochloride and its structure has been settled as 3 by X-ray analysis.The forms of existence of physoperuvine, a free base, and its hydrochloride have been studied, revealing that while the salt remains exclusively in the amino-alcohol form (3), the free base is an equilibrium mixture of the amino-alcohol (1) and the amino-ketone (2), the equilibrium being shifted toward the former.