60723-73-1

Upstream product

• 2656-51-1 1-(2-amino-3-hydroxy-phenyl)-ethanone; hydrochloride 
• 98-88-4 benzoyl chloride 
• 10257-92-8 2-phenyl-3-methyl-1H-indole 

Downstream Products

• 60723-70-8 5-[1-(2-phenyl-benzooxazol-4-yl)-ethylidene]-2-thioxo-thiazolidin-4-one 
• 60723-67-3 (2-phenyl-benzooxazol-4-yl)-acetic acid 
• 60723-75-3 4-[2-(2-phenyl-benzooxazol-4-yl)-thiopropionyl]-morpholine 
• 60723-74-2 3-(2-phenyl-benzooxazol-4-yl)-2-thioxo-butyric acid 
• 60723-69-5 2-(2-phenyl-benzooxazol-4-yl)-propionic acid 

Relevant academic research and scientific papers

One-pot oxidative hydrolysis-oxidative cleavage of 7-borylindoles enables access to: O -amidophenols and 4-acylbenzoxazoles

7-Borylindoles undergo a one-pot oxidative-hydrolysis of the arylboronate and oxidative cleavage of the indole C2-C3 double bond to afford o-amidophenol derivatives. Subsequent cyclisation delivers benzoxazoles bearing an acyl group at C4, a substitution pattern common to fungal-derived benzoxazole alkaloids. Using 7-borylindoles as substrates to access functionalised o-amidophenols circumvents the difficult preparation of these compounds from arenes, streamlining access to substituted 4-acylbenzoxazoles in the process.