60729-69-3

Upstream product

• 5735-97-7 (2-methyl-[1,3]dioxolan-2-yl)-acetic acid 

Downstream Products

• 169888-99-7 1-(2-Methyl-[1,3]dioxolan-2-yl)-3-((R)-toluene-4-sulfinyl)-propan-2-one 
• 1309579-61-0 C₂₅H₃₅NO₄Si 
• 1309579-62-1 C₁₉H₂₁NO₄ 
• 171007-33-3 3-[1-(Benzyl-phenyl-amino)-2-(2-methyl-[1,3]dioxolan-2-yl)-eth-(E)-ylidene]-dihydro-furan-2-one 
• 190778-74-6 (E)-3-(Benzyl-phenyl-amino)-2-cyanomethyl-4-(2-methyl-[1,3]dioxolan-2-yl)-but-2-enoic acid ethyl ester 
• 721916-85-4 methyl (1'R,3S)-5,5-ethylenedioxy-3-(1'-methylbenzylamino)-hexanoate 
• 721916-87-6 methyl (1'R,3R)-5,5-ethylenedioxy-3-(1'-methylbenzylamino)-hexanoate 
• 721916-83-2 methyl 5,5-ethylenedioxy-3-((1'R)-1'-methylbenzylamino)-hex-2-enoate 
• 3187-58-4 methyl orsellinate 

Relevant academic research and scientific papers

A β,β′-ketoaminoester as a valuable tool for the asymmetric construction of substituted homopipecolic esters: Application to a formal synthesis of (+)-Calvine

A highly diastereoselective 1,4-addition involving Davies' lithium amide is employed as the key reaction to prepare, in five steps from ethyl acetoacetate, an enantiomerically pure keto protected β,β′- ketoaminoester. This latter was reacted with aldehydes in an intramolecular Mannich process and furnished a direct and stereoselective access to substituted homopipecolates. The validity of this approach was achieved through a new formal asymmetric synthesis of alkaloid (+)-Calvine.

BENZAZEPINE DERIVATIVES, PROCESS FOR THE PREPARATION OF THE SAME AND USES THEREOF

Compounds of the general formula (I): or salts thereof, which exhibit CCR5 antagonism and exert preventive and therapeutic effects against HIV infections: wherein R1 is a 5- to 6-membered aromatic ring which bears a substituent represented by the general formula: R-Z1-X-Z2- (wherein R1 is hydrogen or optionally substituted hydrocarbyl; X is optionally substituted alkylene; and Z1 and Z2 are each a heteroatom) and may be further substituted, with R being optionally bonded to the aromatic ring to form another ring; Y is optionally substituted imino; and R2 and R3 are each optionally substituted aliphatic hydrocarbyl or an optionally substituted hetero-alicyclic group.

Synthesis of α-Unsubstituted Aldol Adducts Utilizing Enantiomerically Pure β-Keto-δ-Dioxolane Sulfoxides

We report an efficient means to synthesize either enantiomer of α-unsubstituted aldol adduts in high enantiomeric excess through the use of β-keto-δ-dioxolane sulfoxide 4.Through a short sequence of reactions, α-unsubstituted aldol products are obtainable in high yield.

A 5C + 5C Bicycloaromatization Reaction via an Aldol Condensation Cascade: A Regioselective Synthesis of Functionalized Naphthalenes from Acyclic Precursors

A regioselective synthesis of naphthalene derivatives 51 was developed by the reaction of 1,3,5-tris(trimethylsiloxy)-1-methoxyhexa-1,3,5-triene (2) with the 1,3,5-tris-electrophiles 50 and trimethylsilyl triflate.Three carbon-carbon bonds are formed in this aldol condensation cascade, where the regiochemistry is controlled by the different reactivities at the sites of the acyclic precursors.