60729-82-0

Usage

Uses

Used in Pharmaceutical Industry:
(2-Oxo-pyrrolidin-1-yl)-phenyl-acetic acid is used as an intermediate in the synthesis of various pharmaceuticals and organic compounds. Its unique chemical structure allows it to be a key component in the development of new drugs and medications.
Used in Medicinal Chemistry:
(2-Oxo-pyrrolidin-1-yl)-phenyl-acetic acid is used as a building block in medicinal chemistry for the design and synthesis of new compounds with potential therapeutic applications. Its versatility and reactivity make it a valuable tool in the development of novel drugs.
Used in Drug Development:
(2-Oxo-pyrrolidin-1-yl)-phenyl-acetic acid is used in drug development to explore its potential biological and pharmacological activities. Further research is needed to fully understand its properties and potential uses, but it holds promise for the development of new therapeutic agents.

Upstream product

• 85441-75-4 2-(4-chlorobutanamido)-2-phenylacetic acid 
• 2835-06-5 phenylglycin 
• 161745-08-0 methyl α-(2-oxo-1-pyrrolidinyl)methoxy acetate 
• 72762-55-1 alpha-hydroxy-2-oxo-1-pyrrolidineacetic acid 
• 616-45-5 2-pyrrolidinon 
• 60729-85-3 methyl 2-(2-oxopyrrolidin-1-yl)-2-phenylacetate 

Downstream Products

• 60026-93-9 dimethyl 2,3-dihydro-5-phenyl-1H-pyrrolizine-6,7-dicarboxylate 
• 1446308-26-4 (3R)-1-(2-oxo-2-phenylethyl)-3-(2-(2-oxopyrrolidin-1-yl)-2-phenylacetoxy)-1-azoniabicyclo[2.2.2]octane chloride 
• 1446308-25-3 (R)-quinuclidin-3-yl 2-(2-oxopyrrolidin-1-yl)-2-phenylacetate 

Relevant academic research and scientific papers

QUINUCLIDINE ESTERS OF 1-AZAHETEROCYCLYLACETIC ACID AS ANTIMUSCARINIC AGENTS, PROCESS FOR THEIR PREPARATION AND MEDICINAL COMPOSITIONS THEREOF

The invention relates to compounds of formula (I), wherein A, R1, R2, X, m and n are as defined in the specification, as selective M3 receptor antagonists, process for their preparation, composition comprising them and the therapeutic use thereof. Said co

QUINUCLIDINE ESTERS OF 1-AZAHETEROCYCLYLACETIC ACID AS ANTIMUSCARINIC AGENTS, PROCESS FOR THEIR PREPARATION AND MEDICINAL COMPOSITIONS THEREOF

Compounds of formula (I): wherein A, R1, R2, X, m, and n are as defined in the specification, are selective M3 receptor antagonists and may be used in the treatment of, inter alia, a respiratory disease such as asthma and COPD.

1,3-Dipolar cycloadditions of new mesoionic compounds. Synthesis of 1H-pyrrolo[1,2-c]thiazoles, pyrrolizines and 5,6,7,8-tetrahydroindolizines

We studied the 1,3-dipolar cycloaddition reactions between alkyne dipolarophiles and the new mesoionic compounds 2H,5H,7H-thiazolo[4,3-b]oxazol-2-one (12), 2H,5H,7H-pyrrolo[2,1-b]oxazol-2-one (13) and 2H,5H,7H-oxazolo[3,2-a]pyridin-2-one (14). These 1,3-dipoles were prepared in situ by means of cyclodehydration with acetic anhydride of the corresponding α-substituted 4-oxo-3-thiazolidine- (9), 2-oxo-1-pyrrolidine- (10) and 2-oxo-1-piperidineacetic acids (11). The cycloaddition reactions with alkyne dipolarophiles afforded single 1H-pyrrolo[1,2-c]thiazole, pyrrolizine and 5,6,7,8-tetrahydroindolizine derivatives, or a mixture of the two possible regioisomers, depending on whether symmetrical or unsymmetrical alkynes.

Amidoalkylation of Aromatics with Glyoxylic Acid-γ-Lactam Adducts: 2-Pyrrolidinone, Pyroglutamic Acid Amide and Ester

A glyoxylic acid-2-pyrrolidinone adduct leads to N-acyliminium-ion induced intermolecular electrophilic aromatic substitution yielding nitrogen-substituted phenylglycine derivatives, whereas the benzylamide of glyoxylic acid-2-pirrolidinone adduct undergo