607358-64-5

Upstream product

• 77987-49-6 benzyl 2-hydroxyethylcarbamate 
• 108549-21-9 benzyl-N,N,N',N'-tetraisopropylphosphorodiamidite 
• 120-92-3 cyclopentanone 
• 162406-70-4 [2-(benzyloxy-diisopropylamino-phosphanyloxy)-ethyl]-carbamic acid benzyl ester 
• 33496-85-4 (2R,3R)-(3-hydroxymethyl-1,4-dioxa-spiro[4.4]non-2-yl)-methanol 
• 6946-61-8 (2S,3S)-1,4-dioxa-spiro[4.4]nonane-2,3-dicarboxylic acid diethyl ester 
• 607358-63-4 (2R,3R)-[3-(4'-methoxy-benzyloxymethyl)-1,4-dioxa-spiro[4.4]non-2-yl]-methanol 

Downstream Products

• 607358-68-9 hexadecanoic acid {(1R,2R)-1-[benzyloxy-(2-benzyloxycarbonylamino-ethoxy)-phosphoryloxymethyl]-3-(benzyloxy-diisopropylamino-phosphanyloxy)-2-hexanoyloxy}-propyl ester 
• 607358-66-7 hexadecanoic acid {(1R,2R)-3-[benzyloxy-(2-benzyloxycarbonylamino-ethoxy)-phosphoryloxy]-2-hexadecanoyloxy-1-(4'-methoxy-benzyloxymethyl)}-propyl ester 
• 607358-67-8 hexadecanoic acid {(1R,2R)-3-[benzyloxy-(2-benzyloxycarbonylamino-ethoxy)-phosphoryloxy]-2-hexadecanoyloxy-1-hydroxymethyl}-propyl ester 
• 607358-65-6 (2-{benzyloxy-[(2R,3R)-2,3-dihydroxy-4-(4'-methoxybenzyloxymethyl)-butoxy]-phosphoryloxy}-ethyl)-carbamic acid benzyl ester 

Relevant academic research and scientific papers

Synthesis of hybrid lipid probes: Derivatives of phosphatidylethanolamine-extended phosphatidylinositol 4,5-bisphosphate (Pea-PIP2)

The total asymmetric synthesis of a novel hybrid lipid possessing a 2,3-diacylthreitol backbone, rather than a 1,2-diacylglycerol backbone, is described. The title compound, Pea-PIP2, possesses a phosphatidylethanolamine (PE) headgroup at the 1-position and a phosphatidylinositol 4,5- bisphosphate (PtdIns(4,5)P2) headgroup at the 4-position. Reporters (biotin, fluorophores, spin label) were covalently attached to the free amino group of the PE, such that these reporters were targeted to the lipid-water interface. The diacyl moieties allow incorporation of Pea-PIP2 into a lipid bilayer, while the PtdIns(4,5)P2 moiety in the aqueous layer was specifically recognized by PtdIns(4,5)P2-specific binding proteins.