607370-96-7

Basic information

• Product Name: 1H-Pyrrole-1-carboxylic acid, 2-(3-nitrophenyl)-, 1,1-dimethylethyl ester
• CAS NO: 607370-96-7
• Molecular Formula: C15H16N2O4
• Molecular Weight: 288.303
• Mol File: 607370-96-7.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 1H-Pyrrole-1-carboxylic acid, 2-(3-nitrophenyl)-, 1,1-dimethylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrrole-1-carboxylic acid, 2-(3-nitrophenyl)-, 1,1-dimethylethyl ester(607370-96-7)
• EPA Substance Registry System: 1H-Pyrrole-1-carboxylic acid, 2-(3-nitrophenyl)-, 1,1-dimethylethyl ester(607370-96-7)

Safety Data

• Hazardous Substances Data: 607370-96-7(Hazardous Substances Data)

Upstream product

• 585-79-5 m-nitrobromobenzene 
• 135884-31-0 N-boc-2-pyrroleboronic acid 
• 5176-27-2 N-tert-butyloxycarbonyl-pyrrole 
• 99-09-2 3-nitro-aniline 
• 586-36-7 3-nitrophenyldiazonium tetrafluoroborate 

Downstream Products

• 912763-15-6 2-(3-nitrophenyl)-1H-pyrrole 
• 134703-21-2 3‐(1H‐pyrrol‐2‐yl)aniline 
• 528885-52-1 (2-(3-(2-(5-cyclohexyl-1-(3,3-dimethyl-2-oxo-butyl)-2-oxo-1,2-dihydro-3H-1,3,4-benzotriazepin-3-yl)-acetylamino)-phenyl)-pyrrol-1-yl)-acetic acid 
• 942232-17-9 C₃₅H₄₁N₅O₅ 
• 528885-53-2 (2-(3-amino-phenyl)-pyrrol-1-yl)-acetic acid methyl ester 
• 942232-59-9 (2-(3-nitro-phenyl)-pyrrol-1-yl)-acetic acid methyl ester 

Relevant articles and documents

Radical C-H arylations of (hetero)arenes catalysed by gallic acid

Gallic acid efficiently catalyses radical arylations in water-acetone at room temperature. This methodology proved to be versatile and scalable. Therefore, it constitutes a greener alternative to arylation. Moreover, considering that gallic acid is an abundant vegetable tannin, this work also unleashes an alternative method for the reutilisation of bio-wastes.

Diarylureas Containing 5-Membered Heterocycles as CB1 Receptor Allosteric Modulators: Design, Synthesis, and Pharmacological Evaluation

Allosteric modulators have attracted significant interest as an alternate strategy to modulate CB1 receptor signaling for therapeutic benefits that may avoid the adverse effects associated with orthosteric ligands. Here we extended our previous structure-activity relationship studies on the diarylurea-based CB1 negative allosteric modulators (NAMs) by introducing five-membered heterocycles to replace the 5-pyrrolidinylpyridinyl group in PSNCBAM-1 (1), one of the first generation CB1 allosteric modulators. Many of these compounds had comparable potency to 1 in blocking the CB1 agonist CP55,940 stimulated calcium mobilization and [35S]GTP-γ-S binding. Similar to 1, most compounds showed positive cooperativity by increasing [3H]CP55,940 binding, consistent with the positive allosteric modulator (PAM)-antagonist mechanism. Interestingly, these compounds exhibited differences in ability to increase specific binding of [3H]CP55,940 and decrease binding of the antagonist [3H]SR141716. In saturation binding studies, only increases in [3H]CP55,940 Bmax, but not Kd, were observed, suggesting that these compounds stabilize low affinity receptors into a high affinity state. Among the series, the 2-pyrrolyl analogue (13) exhibited greater potency than 1 in the [35S]GTP-γ-S binding assay and significantly enhanced the maximum binding level in the [3H]CP5,5940 binding assay, indicating greater CB1 receptor affinity and/or cooperativity.

Optimization of 1,3,4-benzotriazepine-based CCK2 antagonists to obtain potent, orally active inhibitors of gastrin-mediated gastric acid secretion

Starting from a novel, achiral 1,3,4-benzotriazepine-based CCK2 receptor antagonist, a process of optimization has afforded further compounds of this type that maintain the nanomolar affinity for recombinant, human CCK2 receptors and high selectivity over