607405-17-4

Upstream product

• 84109-76-2 tert-butyl 2-oxocyclopentanecarboxylate 
• 108-24-7 acetic anhydride 
• 150884-50-7 benzaldehyde N-boc imine 
• 474115-96-3 [(3R,3aR,6aR)-2-methyl-3-phenylhexahydro-3aH-cyclopenta[d]isoxazol-3a-yl]methanol 
• 75-36-5 acetyl chloride 
• 3376-23-6 C-phenyl-N-methylnitrone 
• 6140-65-4 1-cyclopentene-1-carboxaldehyde 
• 10472-24-9 methyl 2-oxocyclopentane-1-carboxylate 
• 865086-22-2 benzylidine-carbamic acid allyl ester 

Relevant academic research and scientific papers

Chiral-thiourea-catalyzed direct Mannich reaction

In the presence of a chiral thiourea as a bifunctional organocatalyst, Mannich reaction of N-Boc-imine with prochiral 1,3-dicarbonyl compounds proceeded with excellent enantio- and diastereoselectivities. Georg Thieme Verlag Stuttgart.

Catalytic asymmetric addition of β-ketoesters to various imines by using chiral palladium complexes

A highly enantioselective Mannich-type reaction of β-ketoesters was developed using a catalytic amount of the Pd-aqua complexes 1 (see scheme; PG = protecting group). A variety of imines derived from glyoxylate, as well as simple aromatic and α,β-unsatura

Highly diastereoselective asymmetric Mannich reactions of 1,3-dicarbonyls with acyl imines

The cinchona alkaloids catalyze direct asymmetric Mannich reactions of cyclic 1,3-dicarbonyl compounds with acyl imines to afford α-quaternary carbon-bearing reaction products in yields of up to 98%, a diastereomeric excess of 90% or greater, and enantios

Organocatalysts promote enantioselective 1,3-dipolar cycloadditions of nitrones with 1-cycloalkene-1-carboxaldehydes

In the presence of enantiopure organocatalysts, 1-cycloalkene-1-carboxaldehydes and various nitrones furnished fused isoxazolidines. Thus, some chiral pyrrolidinium salts catalyzed the formation of such cycloadducts in high diastereoand enantioselectivity (up to 92% ee). The predominant diastereomer, the exo one, was mostly obtained in excellent diastereoselectivity (> 99:1 dr). Furthermore, after recrystallization of one of the cycloadducts, this was obtained enantiomerically pure (> 99% ee). The absolute configuration of one of the cycloadducts was determined. Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003.