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Ethyl 4-(2-(4,6-dimethyl-3-oxoisothiazolo[5,4-b]pyridin-2(3H)-yl)acetyl)piperazine-1-carboxylate, also known as YMU1, is a chemical compound that acts as a potent, reversible, and ATP-competitive inhibitor of human Thymidylate kinase (TMPK). It is characterized by its unique molecular structure, which includes an isothiazolo[5,4-b]pyridine moiety and a piperazine-1-carboxylate group.

902589-96-2

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902589-96-2 Usage

Uses

Used in Pharmaceutical Industry:
YMU1 is used as a pharmaceutical agent for the development of treatments targeting human Thymidylate kinase (TMPK). Its potent and reversible inhibition of TMPK makes it a promising candidate for the treatment of diseases associated with abnormal TMPK activity, such as certain types of cancer.
Used in Research Applications:
YMU1 is also used as a research tool in the study of TMPK and its role in various biological processes. Its ATP-competitive nature allows researchers to investigate the enzyme's function and potential therapeutic targets in a controlled manner, providing valuable insights into the development of new drugs and therapies.

Check Digit Verification of cas no

The CAS Registry Mumber 902589-96-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,0,2,5,8 and 9 respectively; the second part has 2 digits, 9 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 902589-96:
(8*9)+(7*0)+(6*2)+(5*5)+(4*8)+(3*9)+(2*9)+(1*6)=192
192 % 10 = 2
So 902589-96-2 is a valid CAS Registry Number.

902589-96-2 Well-known Company Product Price

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  • Sigma

  • (SML0815)  YMU1  ≥98% (HPLC)

  • 902589-96-2

  • SML0815-5MG

  • 983.97CNY

  • Detail
  • Sigma

  • (SML0815)  YMU1  ≥98% (HPLC)

  • 902589-96-2

  • SML0815-25MG

  • 3,970.98CNY

  • Detail

902589-96-2Downstream Products

902589-96-2Relevant academic research and scientific papers

TARGETING HUMAN THYMIDYLATE KINASE INDUCES DNA REPAIR TOXICITY IN MALIGNANT TUMOR CELLS

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, (2012/06/16)

The present invention relates to novel TMPK inhibitor compositions and their methods of use. In particular, it relates to novel TMPK inhibitor compositions and therapeutics that lead to dUTP-mediated DNA repair in tumor cells and acts as a novel chemosensitizer, which are useful in methods for treating or preventing cancers

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