60755-80-8 Usage
Chemical Properties
Pale Yellow Powder
Uses
Sanguinine has a more potent acetylcholinesterase inhibitory activity than galanthamine due to an extra hydroxyl group available for potential interaction with acetylcholinesterase. Sanguinine, in turn, is 10-fold more selective than galanthamine for acetylcholinesterase (AChE) vs. butyrylcholinesterase (BuChE). The lack of AChE inhibitory activity of lycoramine and epinorlicoramine could be due to the occurrence of a double bond in ring C, which does not allow these alkaloids to have the same spatial configuration as the active alkaloids of this series.
Check Digit Verification of cas no
The CAS Registry Mumber 60755-80-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,0,7,5 and 5 respectively; the second part has 2 digits, 8 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 60755-80:
(7*6)+(6*0)+(5*7)+(4*5)+(3*5)+(2*8)+(1*0)=128
128 % 10 = 8
So 60755-80-8 is a valid CAS Registry Number.
InChI:InChI=1/C16H19NO3/c1-17-7-6-16-5-4-11(18)8-13(16)20-15-12(19)3-2-10(9-17)14(15)16/h2-5,11,13,18-19H,6-9H2,1H3/t11-,13-,16-/m0/s1
60755-80-8Relevant articles and documents
Synthesis of deuterium-labelled (-)-galanthamine
Rouleau, Julien,Guillou, Catherine
, p. 236 - 238 (2008/12/20)
The synthesis of deuterium-labelled galanthamine is reported. 6-[ 2H3]methoxy-N-[2H3]methyl-(-)- galanthamine was obtained in seven steps from galanthamine. The synthesis was carried out by selective O- and N-de
Potent acetylcholinesterase inhibitors: Design, synthesis, and structure - Activity relationships of bis-interacting ligands in the galanthamine series
Mary, Aude,Renko, Dolor Zafiarisoa,Guillou, Catherine,Thal, Claude
, p. 1835 - 1850 (2007/10/03)
New galanthamine derivatives, especially bis-interacting ligands 3-5 and 7-9 were prepared in order to interact with the catalytic and the peripheral sites of acetylcholinesterase (AChE). The synthesis, the anticholinesterase activities, and the structure-activity relationships of bis-interacting ligands are reported. Compounds 4d-e were found to be more potent than galanthamine and tacrine in inhibiting AChE. Copyright (C) 1998 Elsevier Science Ltd.
