60756-86-7

Basic information

• Product Name: 4-hydroxypiperidinocyclohexyl carbonitrile
• Synonyms: 4-hydroxypiperidinocyclohexyl carbonitrile
• CAS NO: 60756-86-7
• Molecular Weight: 208.304
• Mol File: 60756-86-7.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 4-hydroxypiperidinocyclohexyl carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 4-hydroxypiperidinocyclohexyl carbonitrile(60756-86-7)
• EPA Substance Registry System: 4-hydroxypiperidinocyclohexyl carbonitrile(60756-86-7)

Safety Data

• Hazardous Substances Data: 60756-86-7(Hazardous Substances Data)

Upstream product

• 5382-16-1 4-HYDROXYPIPERIDINE 
• 108-94-1 cyclohexanone 
• 75-86-5 2-hydroxy-2-methylpropanenitrile 
• 773837-37-9 sodium cyanide 
• 151-50-8 potassium cyanide 
• 5382-17-2 piperidin-4-ol hydrochloride 

Downstream Products

• 60232-85-1 1-(1-phenylcyclohexyl)-4-hydroxypiperidine 
• 1165754-52-8 1-[1-(4-methoxyphenyl) (cyclohexyl)]-4-piperidinol 
• 1165754-50-6 1-[1-(4-methylphenyl) (cyclohexyl)]-4-piperidinol 
• 1372710-25-2 1-[1-[3-hydroxy-5-methylphenyl][cyclohexyl]]-4-piperidinol 
• 77179-34-1 3,4-Dimethoxy-benzoic acid 1-(1-phenyl-cyclohexyl)-piperidin-4-yl ester 
• 77179-37-4 4-Amino-benzoic acid 1-(1-phenyl-cyclohexyl)-piperidin-4-yl ester 
• 77179-36-3 Nicotinic acid 1-(1-phenyl-cyclohexyl)-piperidin-4-yl ester 
• 77179-35-2 Benzoic acid 1-(1-phenyl-cyclohexyl)-piperidin-4-yl ester 

Relevant articles and documents

Synthesis and antinociceptive behaviors of new methyl and hydroxyl derivatives of phencyclidine

Phencyclidine (I) and its derivatives show such pharmacological behaviors as analgesic, anticonsulvant, anti-anxiety and antidepressant, while interacting with central nervous system. In this study, new methyl and hydroxyl derivatives of PCP were synthesized and their antinociceptive behaviors in animals were examined by measuring the number of writhing in a writhing test of visceral pain and the pain scores in Formalin test. Compared to control and PCP groups, findings in experimental groups indicated the new synthesized analogues (compounds II, III and V, 10 mg/kg) of PCP were able to produce more analgesic effects in formalin and writhing tests, especially for compound V. It was concluded that the new synthesized derivatives of PCP could substantially and respectively diminish acute and chronic pains.

1-[1-(2-Benzo[b]thiopheneyl)cyclohexyl]piperidine hydrochloride (BTCP) yields two active primary metabolites in vitro: Synthesis, identification from rat liver microsome extracts, and affinity for the neuronal dopamine transporter

1-[1-(2-Benzo[b]thiopheneyl)cyclohexyl]piperidine hydrochloride (BTCP, 1) and cocaine bind to the neuronal dopamine transporter to inhibit dopamine (DA) reuptake. However, on chronic administration, cocaine produces sensitization, but 1 produces tolerance

Phencyclidine and phencyclidine metabolites assay, tracers, immunogens and antibodies

The present invention is directed to a fluorescence polarization assay for phencyclidine and phencyclidine derivatives, to the various components needed for preparing and carrying out such an assay, and to methods of making these components. Specifically, tracers, immunogens and antibodies are disclosed, as well as methods for making them. The tracers and the immunogens are made from substituted phencyclidine compounds. A fluorescein moiety is included in the tracer, while a poly(amino acid) forms a part of the immunogen. The assay is conducted by measuring the degree of polarization retention of plane polarized light that has been passed through a sample containing antiserum and tracer.