6076-81-9Relevant academic research and scientific papers
Synthesis and in vivo evaluation of 3,4-disubstituted gababutins
Blakemore, David C.,Bryans, Justin S.,Carnell, Pauline,Field, Mark J.,Kinsella, Natasha,Kinsora, Jack K.,Meltzer, Leonard T.,Osborne, Simon A.,Thompson, Lisa R.,Williams, Sophie C.
scheme or table, p. 248 - 251 (2010/04/02)
A range of 3,4-alkylated five-membered ring derivatives of gabapentin were synthesised. One compound (21) had an excellent level of potency against α2δ and was profiled in in vivo models of pain and anxiety.
Stereoselective hydrocoupling of cinnamic acid esters by electroreduction: Application to asymmetric synthesis of hydrodimers
Kise, Naoki,Iitaka, Shumei,Iwasaki, Keisuke,Ueda, Nasuo
, p. 8305 - 8315 (2007/10/03)
The electroreduction of Ar-substituted methyl cinnamates in acetonitrile gave all-trans cyclized hydrodimers stereoselectively (58-90% de). In all cases, small amounts (2-symmetric dl-3,4-diaryladipic acids and trans-3,4-diarylcyclopentanones. The chiral auxiliary [(1R)-exo]-3-exo-(diphenylmethyl)borneol, prepared from (1R)-(+)-camphor, was highly effective for the stereoselective hydrocoupling of its cinnamates by electroreduction. From the resulting hydrodimers, (3R,4R)-3,4-diaryladipic acid esters and (3R,4R)-3,4-diarylhexane-1,6-diols were synthesized in 87-95% ee.
Synthetic Studies towards the Pinguisanes; Synthesis of 4-epi-Pinguisone
Baker, Raymond,Selwood, David L.,Swain, Christopher J.,Webster,Nigel M.H.,Hirshfield, Jordan
, p. 471 - 480 (2007/10/02)
Two procedures have been developed for the synthesis of the appropriate indene skeleton required for construction of pinguisone and 4-epi-pinguisone.Whereas 1-methoxy-3-(trimethylsiloxy)buta-1,3-diene (Danishefsky's diene) was completely unreactive toward
