607685-48-3

Upstream product

• 1241920-56-8 (4S,5R)-1,4-dibenzyloxy-5-methylpyrrolidin-2-one 
• 607685-47-2 (4S,5R)-4-benzyloxy-1-(4-methoxybenzyl)-5-methyl-2-pyrrolidinone 
• 254730-07-9 (S)-4-benzyloxy-1-(4-methoxybenzyl)-2,5-pyrrolidinedione 

Downstream Products

• 607685-49-4 (4S,5R)-4-benzyloxy-1-(tert-butyloxycarbonyl)-5-methyl-2-pyrrolidinone 

Relevant academic research and scientific papers

N-Benzyloxymalimide for an easy access to 5-alkyl-3-pyrrolin-2-ones: Asymmetric synthesis of the mixed imide substructure of the potent immunosuppressant microcolin B

O-Benzyl-N-benzyloxymalimide 12 has been synthesized as a useful variant of the chiral building blocks 9. The advantage of the malimide 12 over 9 was demonstrated by mild and high-yielding reductive N-deprotection of N-benzyloxylactams 18a-i to give a series of (4R,5S)-5-alkyl-4-hydroxy- pyrrolidin-2-ones, which are key intermediates for the asymmetric synthesis of pyrrolidines, pyrrolizidines, and indolizidines, as well as β-hydroxy γ-amino acids. Lactam ent-11a has been applied to the synthesis of the mixed imide 25, a key intermediate for the total synthesis of microcolin B, which also demonstrated that lactam ent-11a or 11a can serve as a latent form of the 5-methyl-3-pyrrolin-2-one substructure of majusculamide D 4, deoxymajusculamide D, and the jamaicamides A-C.

A flexible non-amino acid-based formal asymmetric synthesis of naturally occurring (2R,3S)-2-aminotetradeca-5,7-dien-3-ol: Observation of a remarkable protecting group effect

A flexible non-amino acid-based formal asymmetric synthesis of naturally occurring antimicrobial (2R,3S)-2-aminotetradeca-5,7-dien-3-ol is reported. The method features a flexible and highly regioselective Grignard addition to (S)-malimide followed by a t