254730-07-9

Usage

General Description

2,5-Pyrrolidinedione, 1-[(4-methoxyphenyl)methyl]-3-(phenylmethoxy)-(3S)-, also known as brivudine, is a synthetic nucleoside analogue that is used as an antiviral medication. It has been shown to be effective in the treatment of herpes zoster, also known as shingles, as well as in the prevention of herpes simplex virus reactivation. Brivudine works by interfering with the replication of viral DNA, thereby inhibiting the spread of the virus within the body. It is administered orally and has been found to have a favorable safety profile with few adverse effects. Overall, brivudine plays a crucial role in the management and prevention of viral infections caused by herpes zoster and herpes simplex.

Upstream product

• 2393-23-9 4-methoxy-benzylamine 
• 174874-82-9 acetic acid (3S)-1-(4-methoxy-benzyl)-2,5-dioxo-pyrrolidin-3-yl ester 
• 100-39-0 benzyl bromide 
• 254730-06-8 (S)-4-hydroxy-1-(4-methoxybenzyl)-2,5-pyrrolidinedione 

Downstream Products

• 254730-08-0 (S)-4-Benzyloxy-5-(3-benzyloxy-propyl)-5-hydroxy-1-(4-methoxy-benzyl)-pyrrolidin-2-one 
• 1197026-80-4 C₂₆H₂₇NO₄ 
• 1190758-10-1 C₂₇H₂₉NO₄ 

Relevant academic research and scientific papers

2 - fluorobenzyl to - 3 - hydroxy-pyrrolidine amino acid and its preparation method and anti-cancer activity study

The invention relates to 2-p-luorobenzyl-3-hydroxy pyrrolidine amino acid, and a preparation method and the anticancer activity research thereof, and mainly solves the technical problem that the quantity of the class of compound is low. The compound has the structural formula as the figure shown in the description, wherein R is equal to various amino acids, and amino acids containing aromatic ring is optimized. The synthetic route of the amino acid is as shown in the description. The amino acid mainly inspects the influence on the activity of the class of the compound by groups with electric absorption being introduced in pyrrolidine 2-position.

Asymmetric synthesis of (-)-(R)-pyrrolam A starting from (S)-malic acid

An asymmetric synthesis of natural (-)-pyrrolam A starting from natural (S)-malic acid is described. The stereogenic center was established via a highly trans-diastereoselective reductive alkylation procedure. A tandem base-induced intramolecular amide N-