607708-58-7Relevant academic research and scientific papers
Quantification of a pharmacodynamic erk end point in melanoma cell lysates: Toward personalized precision medicine
Warthaka, Mangalika,Adelmann, Charles H.,Kaoud, Tamer S.,Edupuganti, Ramakrishna,Yan, Chunli,Johnson, William H.,Ferguson, Scarlett,Tavares, Clint D.,Pence, Lindy J.,Anslyn, Eric V.,Ren, Pengyu,Tsai, Kenneth Y.,Dalby, Kevin N.
, p. 47 - 52 (2015)
Protein kinases are mutated or otherwise rendered constitutively active in numerous cancers where they are attractive therapeutic targets with well over a dozen kinase inhibitors now being used in therapy. While fluorescent sensors have capacity to measur
Design and synthesis of fluorescent activity probes for protein phosphatases
Casey, Garrett R.,Beck, Jon R.,Stains, Cliff I.
, p. 29 - 53 (2019/03/11)
Protein phosphatases act in concert with protein kinases to regulate and maintain the phosphoproteome. However, the catalog of chemical tools to directly monitor the enzymatic activity of phosphatases has lagged behind their kinase counterparts. In this c
Modular and tunable chemosensor scaffold for divalent zinc
Shults, Melissa D.,Pearce, Dierdre A.,Imperiali, Barbara
, p. 10591 - 10597 (2007/10/03)
A modular peptide scaffold has been developed for fluorescent sensing of divalent zinc. The signaling component of the chemosensor is the chelation-sensitive fluorophore 8-hydroxy-5-(N,N-dimethylsulfonamido)-2-methylquinoline, which is prepared as the pro
