607731-95-3

Upstream product

• 501-53-1 benzyl chloroformate 
• 607731-94-2 (2S,4R)-4-{2-[dimethyl-(1,1,2-trimethylpropyl)silanyloxy]ethyl}-5-oxopyrrolidine-2-carboxylic acid tert-butyl ester 
• 237421-63-5 tert-butyl (2S,4R)-4-(prop-2-enyl)-pyroglutamate 
• 607732-04-7 (2S,4S)-4-Allyl-5-oxo-pyrrolidine-2-carboxylic acid 
• 365973-11-1 (2S,4S)-4-Allyl-5-oxo-pyrrolidine-2-carboxylic acid methyl ester 

Downstream Products

• 607732-08-1 (2S,4R,5R)-4-{2-[Dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-ethyl}-5-(3-hydroxy-propyl)-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-tert-butyl ester 
• 607731-97-5 (2S,4R,5R)-5-Allyl-4-{2-[dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-ethyl}-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-tert-butyl ester 
• 607731-89-5 (2S,4R,5R)-4-{2-[Dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-ethyl}-5-(3-oxo-propyl)-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-tert-butyl ester 
• 607731-88-4 (2S,4R,5R)-4-{2-[Dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-ethyl}-5-(2-oxo-ethyl)-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-tert-butyl ester 
• 607731-96-4 (2S,4R)-4-{2-[Dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-ethyl}-5-hydroxy-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-tert-butyl ester 

Relevant academic research and scientific papers

Synthesis of substituted conformationally constrained 6,5- and 7,5-fused bicyclic lactams as dipeptide mimics

Using a convenient and practical route we report the preparation of a series of rigid surrogates of amino acids and dipeptides for application within constrained peptide analogues, and for employment as input for combinatorial science. These substituted 2-oxo-1-azabicycloalkane amino acids have the potential of replicating the backbone geometry and side-chain function of dipeptide residues like serine, lysine, glutamate, and related amino acids.