607732-69-4Relevant academic research and scientific papers
A stereocontrolled access to ring-fused piperidines through a formal [2+2+2] process
Godineau, Edouard,Schaefer, Christian,Landais, Yannick
, p. 4871 - 4874 (2006)
(Chemical Equation Presented) A formal [2+2+2] process has been devised that allows the stereocontrolled formation of ring-fused piperidines from allylsilanes possessing an oxime moiety. The cascade involves an intermolecular radical addition of an α-iodoacetate onto an allylsilane double bond, which is followed by a 5-exo-trig cyclization onto an oxime and is completed by the formation of the amide bond by nucleophilic attack of the amine onto the ester function.
Nickel-catalyzed dimerization and carbosilylation of 1,3-butadienes with chlorosilanes and Grignard reagents
Terao, Jun,Oda, Akihiro,Ikumi, Aki,Nakamura, Akifumi,Kuniyasu, Hitoshi,Kambe, Nobuaki
, p. 3412 - 3414 (2003)
In a multicomponent coupling reaction, 1,3-butadienes underwent Ni-catalyzed dimerization and carbosilylation in the presence of a chlorosilane and a Grignard reagent at -20°C (see scheme). The coupling product was obtained regio- and stereoselectively when unsubstituted 1,3-butadiene was used. (R = H, Me, or C9H19; R′, R″ = hydrocarbon substituent.).
