5341-07-1

Basic information

• Product Name: 3-BROMO-8-NITROQUINOLINE
• Synonyms: 8-nitro-3-bromoquinoline;3-BROMO-8-NITROQUINOLINE;Brn 0155665;Nsc 2045;Quinoline, 3-bromo-8-nitro-
• CAS NO: 5341-07-1
• Molecular Formula: C₉H₅BrN₂O₂
• Molecular Weight: 253.05
• Mol File: 5341-07-1.mol
• Article Data: 11

Chemical Properties

• Melting Point: 123-124 °C
• Boiling Point: 358.3°Cat760mmHg
• Flash Point: 170.5°C
• Appearance: /
• Density: 1.7693 (rough estimate)
• Vapor Pressure: 5.32E-05mmHg at 25°C
• Refractive Index: 1.5140 (estimate)
• PKA: -1.26±0.28(Predicted)
• CAS DataBase Reference: 3-BROMO-8-NITROQUINOLINE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-BROMO-8-NITROQUINOLINE(5341-07-1)
• EPA Substance Registry System: 3-BROMO-8-NITROQUINOLINE(5341-07-1)

Safety Data

• Hazardous Substances Data: 5341-07-1(Hazardous Substances Data)

Usage

General Description

3-Bromo-8-nitroquinoline is a chemical compound with the molecular formula C9H6BrNO2. It is a yellow crystalline solid that is used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. The compound has a bromine atom at the 3-position and a nitro group at the 8-position of the quinoline ring. It has potential applications in the field of medicinal chemistry due to its ability to modify the activity of biological targets. 3-Bromo-8-nitroquinoline is also used in the development of fluorescent probes and as a building block in organic synthesis. It is important to handle this compound with caution as it can be harmful if ingested, inhaled, or comes into contact with the skin.

InChI:InChI=1/C9H5BrN2O2/c10-7-4-6-2-1-3-8(12(13)14)9(6)11-5-7/h1-5H

Upstream product

• 88-74-4 2-nitro-aniline 
• 607-35-2 8-nitroquinoline 
• 5332-24-1 3-bromoquinoline 

Downstream Products

• 139399-62-5 8-hydroxy-3-bromoquinoline 
• 497084-48-7 3-iodo-8-quinolinol 

Relevant articles and documents

Effect of 3-subsitution of quinolinehydroxamic acids on selectivity of histone deacetylase isoforms

A series of 3-subsituted quinolinehydroxamic acids has been synthesised and evaluated for their effect on human lung cancer cell line (A549), human colorectal cancer cell line (HCT116) and HDAC isoforms 1, 2, 6, and 8. The results indicated that substitut

QUINOLINE DERIVATIVES FOR DIAGNOSIS AND TREATMENT OF ALZHEIMER'S DISEASE

A new class of quinoline compounds is useful for the detection and treatment of Alzheimer's disease and other neurodegenerative diseases such as amyloidoses and tauopathies. The compounds can be synthesized in radiolabeled form for use as imaging agents,

Synthesis and structure activity relationship of 3-(arylsulfonyl)-8- (piperidin-4-yl amino)quinoline derivatives as 5-HT6 receptor antagonists

As part of our efforts to develop better therapies for the treatment of cognitive impairment associated with Alzheimer's disease and Schizophrenia, we have focused our research towards 5-HT6 receptor (5-HT6R) in order to identify potent and selective ligands for this purpose. Herein, we report the synthesis, structure activity relationship and biological evaluation of a novel series of 3-(arylsulfonyl)-8- (piperidin-4-yl amino)quinoline derivatives, as 5-HT6 receptor (5-HT6R) antagonists. In this work, we have shown that moving from aryl sulfonamide platform to biaryl sulfone platform retains the 5-HT6.R affinity when tested in vitro in cell based reporter gene functional assay.