60801-73-2Relevant academic research and scientific papers
Positional isomerization of quinine and quinidine via rhodium on alumina catalysis: Practical one-step synthesis of Δ3,10-isoquinine and Δ3,10-isoquinidine
Portlock, David E.,Naskar, Dinabandhu,West, Laura,Seibel, William L.,Gu, Titan,Krauss, Howard J.,Peng, X. Sean,Dybas, Paul M.,Soyke, Edward G.,Ashton, Stephen B.,Burton, Jonathan
, p. 5365 - 5368 (2003)
The synthesis of Δ3,10-isoquinine (5Z,5E) and Δ3,10-isoquinidine (6Z,6E) was achieved in one-step through positional isomerization of the terminal alkene in the parent cinchona alkaloids using catalytic amounts of 5% Rh/Al2O3 and excess hydrochloric acid in refluxing 50% aqueous EtOH. The products were obtained in good yields as a mixture of E and Z geometric isomers and fully characterized using spectroscopic methods.
Effect of Microwave Irradiation on the Catalytic Activity of Palladium Supported Catalysts in the One-Step Isomerisation of Cinchona Alkaloids to Δ3,10-Isobases
Lipińska, Teodozja M.,Borowska, Dominika,Sw?dra, Natalia,Trochim, Katarzyna
, p. 2835 - 2843 (2017/09/14)
Abstract: Efficiency of palladium solid supported (Pd/SS) catalysts for one-step isomerisation of the side chain of four natural Cinchona alkaloids have been explored under controlled microwave heating in the green media (50% aqueous ethanol or ethylene g
Hydrogenation of prochiral ketones
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Page/Page column 6, (2010/01/31)
Process for enantioselectively hydrogenating prochiralen ketones to (S)-alcohols using platinum catalysts in the presence of cinchonines or quinidines as modifiers and in the presence of hydrogen, which is characterized in that the modifiers used are cinchonines unsubstituted in the 3-position, 3-ethylidenyl- or 9-methoxycinchonines or derivatives thereof in which the quinoline ring is replaced by other rings.
