608122-63-0

Upstream product

• 608128-83-2 (5S)-3,4-dehydroclausenamidone 
• 648909-27-7 (2R,3R)-3-Phenyl-oxirane-2-carboxylic acid (2-hydroxy-2-phenyl-ethyl)-methyl-amide 
• 190771-98-3 (2R,3S)-2,3-Dihydroxy-N-<(2'RS)-2'-hydroxy-2'-phenylethyl>-N-methylpropanamide 
• 648909-28-8 (2R,3R)-3-Phenyl-oxirane-2-carboxylic acid methyl-(2-oxo-2-phenyl-ethyl)-amide 

Downstream Products

• 608128-75-2 (3S,4S,5S)-3-hydroxy-5-((R)-hydroxy(phenyl)methyl)-1-methyl-4-phenylpyrrolidin-2-one 
• 608122-69-6 (-)-3S,4S,5R-cisneoclausenamidone 

Relevant academic research and scientific papers

Synthesis and activity in enhancing long-term potentiation (LTP) of clausenamide stereoisomers

Clausenamide, isolated from aqueous extract of dry leaves of Clausena lansium, a Chinese folk medicine, was found to have potent activity in enhancing LTP and show nootropic activity in animal tests. In order to discovery more potent stereoisomers and to

A concise total synthesis of (-)-dehydroclausenamide utilizing the novel formation of cis-epoxide as the key step

The asymmetric total synthesis of (-)-dehydroclausenamide 1 was accomplished through a concise and efficient synthetic route employing as the key step the novel formation of cis-epoxy amide 7, which was resulted from the reaction of starting material 4 bearing an optically pure erythro vicinal diol unit with 5H-3-oxa-octafluoro pentanesulfonyl fluoride (HCF2CF 2OCF2CF2SO2F) in the presence of 1,8-diazabicyclo[5.4.0]-7-undecene (DBU).