608141-09-9

Upstream product

• 52289-93-7 o-Methoxybenzyl bromide 
• 1210-57-7 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline-1-carbonitrile 
• 120-20-7 2-(3,4-dimethoxyphenyl)-ethylamine 
• 28033-63-8 2-(2-methoxyphenyl)acetyl chloride 
• 93-25-4 2-methoxyphenylacetic acid 
• 351155-93-6 (2-methoxy-phenyl)-acetic acid-(3,4-dimethoxy-phenethylamide) 

Downstream Products

• 1356165-53-1 6,7-dimethoxy-2-[2-(2-methoxyphenyl)ethyl]-3,4-dihydroisoquinolinium trifluoroacetate 

Relevant academic research and scientific papers

1,3-benzyl migration in iminium ions: Evidence for a fast free-radical chain reaction

The "exocyclic" 1,3-benzyl shift observed in iminium salts derived from 1-benzyl-1,2,3,4-tetrahydroisoquinolines is related to the "endocyclic" Knabe rearrangement. A crossover experiment, isotopic labelling, the study of initiators and inhibitors as well as DFT calculations of gas-phase model structures provide evidence for a free-radical pathway under kinetic entropy control that is not affected by "slow" radical traps. An unexpected rearrangement of methyleneiminium ions derived from 1-benzyl-1,2,3,4-tetrahydroisoquinolines has been investigated by isotopic labelling, trapping experiments and DFT calculations. Theobserved benzyl migration proceeds by an exceptionally fast radical chain reaction closely related to the Knabe reaction.Remarkably, the process is inhibited byneither methyl acrylate nor dioxygen. Copyright

Antiplatelet activity of synthetic pyrrolo-benzylisoquinolines

Pyrrolo-benzylisoquinolines were prepared as target compounds and their antiplatelet aggregation activity, adreno-receptor affinity, and cytotoxicity were screened. Compounds 1d-9d showed specific antiplatelet aggregation activity induced by arachidonic acid and collagen. Among them, 8d and 9d exhibited better activity than the reference drug, aspirin and 9d also showed inhibition of platelet aggregation by all four inducers.