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608145-94-4

2-Butenoic acid, 4-(2-formyl-4,5-dimethoxyphenoxy)-, ethyl ester, (2E)- is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 608145-94-4 Structure

  • Basic information

    1. Product Name: 2-Butenoic acid, 4-(2-formyl-4,5-dimethoxyphenoxy)-, ethyl ester, (2E)-
    2. Synonyms:
    3. CAS NO:608145-94-4
    4. Molecular Formula: C15H18O6
    5. Molecular Weight: 294.304
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 608145-94-4.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 2-Butenoic acid, 4-(2-formyl-4,5-dimethoxyphenoxy)-, ethyl ester, (2E)-(CAS DataBase Reference)
    10. NIST Chemistry Reference: 2-Butenoic acid, 4-(2-formyl-4,5-dimethoxyphenoxy)-, ethyl ester, (2E)-(608145-94-4)
    11. EPA Substance Registry System: 2-Butenoic acid, 4-(2-formyl-4,5-dimethoxyphenoxy)-, ethyl ester, (2E)-(608145-94-4)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 608145-94-4(Hazardous Substances Data)

608145-94-4 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 608145-94-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 6,0,8,1,4 and 5 respectively; the second part has 2 digits, 9 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 608145-94:
(8*6)+(7*0)+(6*8)+(5*1)+(4*4)+(3*5)+(2*9)+(1*4)=154
154 % 10 = 4
So 608145-94-4 is a valid CAS Registry Number.

608145-94-4Relevant articles and documents

Synthesis of 3a,4-dihydro-3H-[1]benzopyrano[4,3-c]isoxazoles, displaying combined 5-HT uptake inhibiting and α2-adrenoceptor antagonistic activities: A novel series of potential antidepressants

Andres, J. Ignacio,Alcazar, Jesus,Alonso, Jose M.,Alvarez, Rosa M.,Cid, Jose M.,De Lucas, Ana I.,Fernandez, Javier,Martinez, Sonia,Nieto, Carmen,Pastor, Joaquin,Bakker, Margot H.,Biesmans, Ilse,Heylen, Lieve I.,Megens, Anton A.

, p. 2719 - 2725 (2003)

The synthesis of a series of novel 3-piperazinylmethyl-3a,4-dihydro-3H-[1]benzopyrano[4,3-c]isoxazoles as novel dual 5-HT reuptake inhibitors and α2-adrenoceptor antagonists is described. Their affinity at the three different human α2-adrenoceptor subtypes and the 5-HT transporter site is reported. The in vivo activity of the compounds was measured in two different assays: (1) inhibition of pCA-induced excitation, which evaluates the ability to block the central 5-HT transporter, and (2) inhibition of xylazine-induced loss of righting, which evaluates the ability to block central α2-adrenoceptors.

Discovery of a new series of centrally active tricyclic isoxazoles combining serotonin (5-HT) reuptake inhibition with α2- adrenoceptor blocking activity

Andrés, J. Ignacio,Alcázar, Jesús,Alonso, José M.,Alvarez, Rosa M.,Bakker, Margot H.,Biesmans, Ilse,Cid, José M.,De Lucas, Ana I.,Fernández, Javier,Font, Luis M.,Hens, Koen A.,Iturrino, Laura,Lenaerts, Ilse,Martínez, Sonia,Megens, Anton A.,Pastor, Joaquín,Vermote, Patrick C. M.,Steckler, Thomas

, p. 2054 - 2071 (2007/10/03)

The synthesis and pharmacology of a new series of 3-piperazinylmethyl-3a,4- dihydro-3H-[1]-benzopyrano[4,3-c]isoxazoles that combine central serotonin (5-HT) reuptake inhibition with α2-adrenoceptor blocking activity is described as potential antidepressants. Four compounds were selected for further evaluation, and the combination of both activities was found to be stereoselective, residing mainly in one enantiomer. Reversal of the loss of righting induced by the α2-agonist medetomidine in rats confirmed the α2-adrenoceptor blocking activity in vivo and also demonstrated CNS penetration. Antagonism of p-chloroamphetamine (pCA)-induced excitation as well as blockade of the neuronal 5-HT depletion induced by p-CA administration in rats confirmed their ability to block the central 5-HTT, even after oral administration. Replacement of the oxygen atom at the 5-position of the tricyclic scaffold by a nitrogen or a carbon atom, as well as O-substitution at position 7, led also to active compounds, both in vitro and in vivo.

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