608145-95-5Relevant academic research and scientific papers
Intramolecular Tandem Seleno-Michael/Aldol Reaction: A Simple Route to Hydroxy Cyclo-1-ene-1-carboxylate Esters
Banachowicz, Piotr,Mlynarski, Jacek,Buda, Szymon
, p. 11269 - 11277 (2018/09/06)
Intramolecular tandem seleno-Michael/aldol reaction followed by an oxidation-elimination process can be an efficient tool for the construction of hydroxy cyclo-1-ene-1-carboxylate esters from oxo-α,β-unsaturated esters. Generation of lithium selenolate from elemental selenium and n-BuLi provides a simple and efficient one-pot access to cyclic endo-Morita-Baylis-Hillman adducts.
Constrained TRPV1 agonists synthesized via silver-mediated intramolecular azo-methine ylide cycloaddition of α-iminoamides
Painter, Thomas O.,Kaszas, Krisztian,Gross, Jacklyn,Douglas, Justin T.,Day, Victor W.,Iadarola, Michael J.,Santini, Conrad
, p. 963 - 968 (2014/02/14)
As part of an effort to identify agonists of TRPV1, a peripheral sensory nerve ion channel, high throughput screening of the NIH Small Molecule Repository (SMR) collection identified MLS002174161, a pentacyclic benzodiazepine. A synthesis effort was initi
Organocatalytic asymmetric intramolecular [3+2] cycloaddition: A straightforward approach to access multiply substituted hexahydrochromeno[4,3-b] pyrrolidine derivatives in high optical purity
Li, Nan,Song, Jin,Tu, Xi-Feng,Liu, Bin,Chen, Xiao-Hua,Gong, Liu-Zhu
supporting information; experimental part, p. 2016 - 2019 (2010/07/04)
A chiral phosphoric acid-catalyzed intramolecular 1,3-dipolar cycloaddition of 4-(2-formylphenoxy)butenoates with amino esters provides hexahydromeno[4,3-b]pyrrolidine derivatives in high enantioselectivity (up to 94% ee).
Synthesis of 3a,4-dihydro-3H-[1]benzopyrano[4,3-c]isoxazoles, displaying combined 5-HT uptake inhibiting and α2-adrenoceptor antagonistic activities: A novel series of potential antidepressants
Andres, J. Ignacio,Alcazar, Jesus,Alonso, Jose M.,Alvarez, Rosa M.,Cid, Jose M.,De Lucas, Ana I.,Fernandez, Javier,Martinez, Sonia,Nieto, Carmen,Pastor, Joaquin,Bakker, Margot H.,Biesmans, Ilse,Heylen, Lieve I.,Megens, Anton A.
, p. 2719 - 2725 (2007/10/03)
The synthesis of a series of novel 3-piperazinylmethyl-3a,4-dihydro-3H-[1]benzopyrano[4,3-c]isoxazoles as novel dual 5-HT reuptake inhibitors and α2-adrenoceptor antagonists is described. Their affinity at the three different human α2-adrenoceptor subtypes and the 5-HT transporter site is reported. The in vivo activity of the compounds was measured in two different assays: (1) inhibition of pCA-induced excitation, which evaluates the ability to block the central 5-HT transporter, and (2) inhibition of xylazine-induced loss of righting, which evaluates the ability to block central α2-adrenoceptors.
