60824-68-2

Upstream product

• 4685-47-6 3,4-dimethylanisole 
• 64-19-7 acetic acid 
• 4370-50-7 4,5-dimethyl-[1,2]benzoquinone 
• 60824-67-1 2,4-Dimethoxy-4,5-dimethyl-2,5-cyclohexadienon 
• 108-24-7 acetic anhydride 

Relevant academic research and scientific papers

Direct Acetoxylation of Arenes

Acetoxylation of arenes is an important reaction and an unmet need in chemistry. We report a metal-free, direct acetoxylation reaction using sodium nitrate under an anhydrous environment of trifluoroacetic acid, acetic acid, and acetic anhydride. Arenes (31 examples), with oxidation potentials (Eox, in V vs SCE) lower than benzene (2.48 V), were acetoxylated with good yields and regioselectivity. A stepwise, single electron-transfer mechanism is proposed.