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2-(4-Methylphenyl)-1H-imidazo[4,5-f][1,10]phenanthroline (also referred to as PMIP or 2-p-tolyl-1H-imidazo[4,5-f][1,10]phenanthroline) is a polypyridyl ligand synthesized from 1,10-phenanthroline-5,6-dione and 4-methylbenzaldehyde. It serves as a versatile chelating agent, forming stable complexes with transition metals such as Ru(II), Co(II), Ni(II), and Cu(II), which exhibit DNA-binding properties and antibacterial activity. The ligand's structure, featuring an imidazole-fused phenanthroline core with a 4-methylphenyl substituent, enhances its coordination ability and influences the photophysical and biochemical behaviors of its metal complexes. **Return paragraph:** 2-(4-Methylphenyl)-1H-imidazo[4,5-f][1,10]phenanthroline is a polypyridyl ligand used in coordination chemistry to form metal complexes with applications in DNA interaction studies and antibacterial research. Its structure, derived from 1,10-phenanthroline and 4-methylbenzaldehyde, enables strong binding to transition metals, modulating their functional properties.

608521-18-2

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608521-18-2 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 608521-18-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 6,0,8,5,2 and 1 respectively; the second part has 2 digits, 1 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 608521-18:
(8*6)+(7*0)+(6*8)+(5*5)+(4*2)+(3*1)+(2*1)+(1*8)=142
142 % 10 = 2
So 608521-18-2 is a valid CAS Registry Number.

608521-18-2Relevant articles and documents

Effects of the ancillary ligands of polypyridyl ruthenium(II) complexes on the DNA-binding behaviors

Xu, Hong,Zheng, Kang-Cheng,Deng, Hong,Lin, Li-Jun,Zhang, Qian-Ling,Ji, Liang-Nian

, p. 1255 - 1263 (2003)

A new polypyridyl ligand PMIP {PMIP = 2-(4-methylphenyl)imidazo[4,5-f]1,10-phenanthroline}, and its Ru(II) complexes, [Ru(bpy)2PMIP]2+ 1 (bpy = 2,2′-bipyridine), [Ru(phen)2PMIP]2+ 2 (phen = 1,10-phenanthroline)

Synthesis, characterization and antibacterial activity of 2-p-tolyl-1h-imidazo[4,5-f][1,10]phenanthroline and its Co(II), Ni(II) and Cu(II) complexes

Gomleksiz, Mesut,Alkan, Cihan,Erdem, Belgin

, p. 213 - 220 (2013)

In this study, the ligand, 2-p-tolyl-1H-imidazo[4,5-f][1,10]phenanthroline (L) was synthesized by the reaction of 1,10-phenanthroline-5,6-dione with 4-methylbenzaldehyde. The complexes of L were prepared with Co(II), Ni(II) and Cu(II) chlorides. The ligan

New iridium complexes(III) bearing 2-phenylimidazo[4,5-f][1,10]-phenanthroline ligand: Synthesis, characterization, electrochemical and photoluminescence studies

Sahin, Cigdem,Sahin, Murat

, (2020/10/18)

Iridium complexes bearing 2-phenylimidazo[4,5-f]-[1,10]-phenanthroline with different substituents (-CH3, -CH(CH3)2, -OCH3, -C6H5) were synthesized and characterized. The effects of differe

Oxovanadium phenanthroimidazole derivatives: synthesis, DNA binding and antitumor activities

Bai, Yin-Liang,Zhang, Ya-Wu,Xiao, Ji-Yuan,Guo, Hai-Wei,Liao, Xiang-Wen,Li, Wen-Jie,Zhang, You-Cheng

, p. 171 - 183 (2018/02/06)

Four unsymmetrical oxovanadium phenanthroimidazole complexes, [VO(hntdtsc)(NPIP)] (1), [VO(hntdtsc)(CPIP)] (2), [VO(hntdtsc)(MEPIP)] (3) and [VO(hntdtsc)(HPIP)] (4) (hntdtsc?=?2-hydroxy-1-naphthaldehyde thiosemicarbazone, NPIP?=?2-(4-nitrophenyl)-imidazo[

Imidazo [4,5f][1,10] phenanthroline derivatives as inhibitor of c-myc gene expression in A549 cells via NF-κB pathway

Sun, Dong-Dong,Wang, Wei-Zhang,Mao, Jian-Wen,Mei, Wen-Jie,Liu, Jie

, p. 102 - 105 (2012/03/10)

1,10-Phenanthroline has been shown to exhibit anticancer activity. Here, a series of imidazo [4,5f][1,10] phenanthroline derivatives 1-10 were synthesized and their biological activities were further elucidated. We found that 2-(4-Brominephenyl)-imidazo [

Antibacterial and superoxide dismutase activity as well as DNA interactions of ciprofloxacin-based ternary copper(II) phenanthroline complexes

Patel, Mohan N.,Dosi, Promise A.,Bhatt, Bhupesh S.

experimental part, p. 1602 - 1611 (2011/11/11)

Five neutral mixed-ligand mononuclear square-pyramidal copper(II) complexes of the type [Cu(cpf)(Ln)Cl] (cpf = ciprofloxacin and Ln = phenanthroline derivatives) (1-5) were synthesized and characterized. The complexes were screened f

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