608530-25-2Relevant academic research and scientific papers
Stereocontrolled synthesis of novel 6′(α)-hydroxy carbovir analogues
Hong, Joon Hee,Oh, Chang-Hyun,Cho, Jung-Hyuck
, p. 6103 - 6108 (2003)
This paper describes the racemic and stereoselective synthetic route for a novel 6′(α)-hydroxy-carbovir from a simple acyclic precursor, Solketal. The relative stereochemistry of the target nucleosides was successfully controlled by a sequential stereoselective glycolate Claisen rearrangement followed by a ring-closing metathesis (RCM). Adenine and cytosine were coupled using a Pd(0) catalyzed allylic alkylation strategy in a high regio- and stereoselective manner.
