608530-22-9Relevant academic research and scientific papers
Stereocontrolled synthesis of novel 6′(α)-hydroxy carbovir analogues
Hong, Joon Hee,Oh, Chang-Hyun,Cho, Jung-Hyuck
, p. 6103 - 6108 (2007/10/03)
This paper describes the racemic and stereoselective synthetic route for a novel 6′(α)-hydroxy-carbovir from a simple acyclic precursor, Solketal. The relative stereochemistry of the target nucleosides was successfully controlled by a sequential stereoselective glycolate Claisen rearrangement followed by a ring-closing metathesis (RCM). Adenine and cytosine were coupled using a Pd(0) catalyzed allylic alkylation strategy in a high regio- and stereoselective manner.
The synthesis of a sulfone containing analogue of the esperamicin-A1 aglycone: A hetero Diels-Alder approach
Prabhakaran, Jaya,Lhermitte, Hervé,Das, Jagattaran,Sasi-Kumar,Grierson, David S.
, p. 658 - 662 (2007/10/03)
The hetero Diels-Alder reaction of methyl/ethyl thioglyoxylate, generated in situ from the corresponding anthracene adduct, with a series of dienes was studied as a route to a key 3,4-dihydro-2H-thiopyran derivative bearing an acetylene function at C-2, a
