608537-17-3Relevant articles and documents
Synthesis of ring size seco-analogs of the antitumor antibiotic CC-1065 by two consecutive transition metal-initiated transformations
Tietze, Lutz F.,Looft, Jan,Feuerstein, Tim
, p. 2749 - 2755 (2003)
Novel seco-analogs of CC-1065 1 were synthesized from comercially available nitroaniline by reduction, bromination, bisulfonation and bisallylation followed by reaction with tert-butyllithium, zirconocene and iodine. The obtained quinoline 6 was then transformed into 17 and 18, which, upon treatment with Pd0, led to 21 and 22, respectively. Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003.