60860-24-4

Basic information

• Product Name: 2-Methoxyimino-2-cyanoacetamide
• Synonyms: 2-Cyano-2-(methoxyimino)acetamide; acetamide, 2-cyano-2-(methoxyimino)-
• CAS NO: 60860-24-4
• Molecular Formula: C4H5N3O2
• Molecular Weight: 127.1
• Mol File: 60860-24-4.mol
• Article Data: 2

Chemical Properties

• Melting Point: 172 °C(Solv: water (7732-18-5))
• Boiling Point: 219.786°C at 760 mmHg
• Flash Point: 86.724°C
• Appearance: /
• Density: 1.299g/cm³
• Vapor Pressure: 0.117mmHg at 25°C
• Refractive Index: 1.523
• PKA: 11.83±0.50(Predicted)
• CAS DataBase Reference: 2-Methoxyimino-2-cyanoacetamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Methoxyimino-2-cyanoacetamide(60860-24-4)
• EPA Substance Registry System: 2-Methoxyimino-2-cyanoacetamide(60860-24-4)

Safety Data

• Hazardous Substances Data: 60860-24-4(Hazardous Substances Data)

Usage

InChI:InChI=1/C4H5N3O2/c1-9-7-3(2-5)4(6)8/h1H3,(H2,6,8)

Upstream product

• 57967-36-9 2-Acetoxyimino-cyanessigsaeureamid 
• 77-78-1 dimethyl sulfate 
• 107-91-5 cyanoacetic acid amide 
• 110-46-3 isopentyl nitrite 
• 2315-36-8 2-Chloro-N,N-diethylacetamide 
• 3849-20-5 2-cyano-2-oximinoacetamide 

Downstream Products

• 5516-13-2 2-methoxyiminomalononitrile 

Relevant articles and documents

Synthesis process of 2-(5-amino-1,2,4-thiadiazol-3-yl)-2-(methoxyimino)acetic acid

The invention relates to a synthesis process of 2-(5-amino-1,2,4-thiadiazol-3-yl)-2-(methoxyimino)acetic acid. With cyanoacetamide serving as a starting material, 2-(5-amino-1,2,4-thiadiazol-3-yl)-2-(methoxyimino)acetic acid is obtained through a hydroxyl oximation reaction, a methylation reaction, a cyclization reaction, a nitrile hydrolysis reaction and the like. Particularly, due to the fact that hydroxyapatite is added in the fifth step to serve as a catalyst, the yield of the intermediate product 2-(5-amino-1,2,4-thiadiazol-3-yl)-2-(methoxyimino)acetonitrile and the total yield of the final product 2-(5-amino-1,2,4-thiadiazol-3-yl)-2-(methoxyimino)acetic acid can be effectively increased, and compared with the total yield not exceeding 9% in the prior art, the total yield of the technical scheme reaches 13% or so and is substantially increased; cost is lowered; industrial large-scale application is facilitated.