60895-05-8

Upstream product

• 64270-11-7 3-hydroxy-3-methyl-1-iodo-1-trans-octene 
• 73886-18-7 (E)-1-iodo-3-methyl-3-[(trimethylsilyl)oxy]-1-octene 
• 39178-64-8 (E)-1-iodo-1-octen-3-one 
• 57403-09-5 7-[(1S,2S)-2-((E)-3-Hydroxy-3-methyl-oct-1-enyl)-5-oxo-cyclopentyl]-heptanoic acid ethyl ester 

Relevant academic research and scientific papers

Total synthesis of 11-deoxy-15-substituted prostaglandins

Processes for the total synthesis of dl-11-deoxy-15-substituted prostaglandins, novel intermediates therefore, certain novel final products, as well as optical resolutions of the final products are disclosed. The final products are bronchodilators.

Alkyl derivatives of prostanoic acids and preparation thereof

15- And/or 16-alkyl derivatives of 9,15-dioxygenated prost-13-enoic, prosta-4,13-dienoic and prosta-5,13-dienoic acid, lower alkyl esters thereof and homologs thereof, as well as a process for preparing these derivatives are disclosed. The compounds possess hypotensive, antihypertensive, bronchospasmolytic, gastric acid secretion inhibiting, abortifacient, estrus synchronizing and ovulation regulating properties. The compounds also inhibit the aggregation of platelets and promote the disaggregation of aggregated platelets. Methods for their use are also disclosed.

11-Deoxy 15-methyl prostaglandin E1

11-Deoxy-prostaglandin compounds having a lower alkyl group at position-15 are prepared from PGA2 esters and 15-epimers. These 15-lower alkyl-11-deoxy prostaglandins possess bronchodilative ability.