60900-18-7

Upstream product

• 60900-14-3 1-benzyl-3-ethyl-1,2,5,6-tetrahydropyridine 
• 100-39-0 benzyl bromide 
• 536-78-7 3-ethylpyridine 
• 55077-15-1 1-benzyl-3-ethylpyridinium bromide 

Downstream Products

• 73657-71-3 1-Benzyl-2-cyano-3-ethyl-3-piperideine 
• 147185-15-7 1-benzyl-3-ethyl-5,6-dihydropyridinium trifluoroacetate 
• 73658-10-3 1-benzyl-2-cyano-2-deuterio-3-ethyl-3-piperideine 
• 73658-11-4 1-benzyl-2-cyano-2-methyl-3-ethyl-3-piperideine 
• 851986-03-3 1-benzyl-4-ethoxy-3-methyl-1,4,5,6-tetrahydropyridine 

Relevant academic research and scientific papers

Synthesis of new azocine derivatives and their functionalization by nucleophilic addition to their iminium salts

A route to the eight-membered nitrogen heterocycles 20a,b is described starting from the 3-alkyl-N-benzylpyridinium salts 14a,b. These azocine derivatives were converted into their respective iminium salts 11 by treatment with methanesulfonic acid. A stud

On the preparation of amine N-oxides by using dioxiranes

The reaction of heterocyclic aromatic amines, anilines and tertiary amines with dimethyldioxirane (DMD) was examined. Treatment of heterocyclic aromatic amines and anilines with a slight excess of DMD at 0°C afforded the corresponding N-oxides in quantitative conversion yields. In addition, the oxidation was chemoselective in the presence of carbon-carbon double bonds. On the other hand, most of the tertiary amines assayed did afford also quantitative yields of the corresponding N. oxides, although reaction conditions, in particular regarding the amount of DMD required, depended on each substrate. Additional studies carried out on selected substrates suggested that certain N-oxides derived from tertiary amines deactivate DMD.

Use of Dioxiranes for the Chemoselective Oxidation of Tertiary Amines bearing Alkene Moieties

A neat and high yield chemoselective epoxidation of alkene moieties present in tertiary amines is accomplished by treatment of the corresponding amine-boron trifluoride adduct with dimethyldioxirane or methyl(trifluoromethyl)dioxirane.

2-Cyano-Δ3-piperideines. 12. Stereochemistry of Formation of N-Benzyl-2-cyano-Δ3-piperideines and Facile Isomerization on Alumina to 2-Cyano-Δ4-piperideines. A Potentially General Route to the Synthesis of 2,6-Disubstitute

The reaction of the piperideine N-oxides 1a-f with trifluoroacetic anhydride in CH2Cl2 at 0 deg C (Polonovski-Potier reaction) led to the formation of the N-benzyl-2-cyano-Δ3-piperideines 3a-f.Epimeric mixtures were obtained for the amino nitri