6093-74-9

Basic information

• Product Name: CHEMBRDG-BB 5873913
• Synonyms: CHEMBRDG-BB 5873913;OTAVA-BB BB7020390500;2-OXO-7-PROPOXY-2H-CHROMENE-3-CARBOXYLIC ACID;OTAVA-BB 7020390500;2-oxo-7-propoxy-2H-chromene-3-carboxylic acid(SALTDATA: FREE);7-propoxycoumarin-3-carboxylic acid
• CAS NO: 6093-74-9
• Molecular Formula: C₁₃H₁₂O₅
• Molecular Weight: 248.233
• Mol File: 6093-74-9.mol
• Article Data: 7

Chemical Properties

• Melting Point: 199-200 °C
• Boiling Point: 540.7°Cat760mmHg
• Flash Point: 280.8°C
• Appearance: /
• Density: 1.37g/cm³
• Vapor Pressure: 9.36E-12mmHg at 25°C
• Refractive Index: 1.708
• PKA: 1.91±0.20(Predicted)
• CAS DataBase Reference: CHEMBRDG-BB 5873913(CAS DataBase Reference)
• NIST Chemistry Reference: CHEMBRDG-BB 5873913(6093-74-9)
• EPA Substance Registry System: CHEMBRDG-BB 5873913(6093-74-9)

Safety Data

• Hazardous Substances Data: 6093-74-9(Hazardous Substances Data)

Usage

InChI:InChI=1/C18H20N6O/c1-22-16(25)23(2)18(14-11-7-4-8-12-14)17(22,21-15(19)24(18)20)13-9-5-3-6-10-13/h3-12H,20H2,1-2H3,(H2,19,21)

Upstream product

• 106-94-5 propyl bromide 
• 105-53-3 diethyl malonate 
• 95-01-2 2,4-Dihydroxybenzaldehyde 
• 6093-71-6 7-hydroxy-2-oxo-2H-chromene-3-carboxylic acid ethyl ester 
• 107-08-4 1-iodo-propane 
• 79065-63-7 7-propoxycoumarin-3-carboxylic acid ethyl ester 

Downstream Products

• 6093-73-8 7-propoxy-2H-chromen-2-one 

Relevant articles and documents

Coumarin hybrid pyridinone amide derivative with potential anti-AD activity and preparation method and application of derivative

The invention discloses a coumarin hybrid pyridinone amide derivative and a preparation method and application thereof. The coumarin hybrid pyridinone amide derivative and pharmacologically acceptablesalt thereof are shown in the formula (I) and the formula (II), and the derivative can be used for preparing drugs for resisting the Alzheimer's disease, the Parkinson's disease or treating other diseases or symptoms by suppressing monoamine oxidase, chelating metallic iron ions, resisting A and resisting oxidation.

Design, synthesis and biological evaluation of coumarin-based N-hydroxycinnamamide derivatives as novel histone deacetylase inhibitors with anticancer activities

A series of novel coumarin-based N-hydroxycinnamamide derivatives were designed and synthesized as histone deacetylase (HDAC) inhibitors. Most of the synthesized compounds showed potent HDAC inhibitory activity and significant antiproliferative activity a

Synthesis and anticholinesterase activity of coumarin-3-carboxamides bearing tryptamine moiety

A number of N-(2-(1H-indol-3-yl)ethyl)-2-oxo-2H-chromene-3-carboxamides were synthesized and tested against AChE and BuChE. The in?vitro assessment of the synthesized compounds 4a-o revealed that most of them had significant activity toward AChE. The SAR study demonstrated that the introduction of benzyloxy moiety on the 7-position of coumarin scaffold can improve the anti-AChE activity. The best result was obtained with 7-(4-fluorobenzyl)oxy moiety in the case of compound 4o, displaying IC50value of 0.16?μM. Based on the docking study of AChE, the prototype compound 4o was laid across the active site and occupied both peripheral anionic site (PAS) and catalytic anionic site (CAS).