609342-43-0Relevant articles and documents
The synthesis and 16S A-site rRNA recognition of carbohydrate-free aminoglycosides
Wang, Xiaojing,Migawa, Michael T.,Sannes-Lowery, Kristin A.,Swayze, Eric E.
, p. 4919 - 4922 (2007/10/03)
The first carbohydrate-free aminoglycoside analogs bearing the 2-deoxystreptamine moiety were synthesized from asymmetrically protected 2-deoxystrepamine and subsequently demonstrated to have significant binding to the 16S A-site rRNA target and moderate
Antimicrobial 2-deoxystreptamine compounds
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Page column 22, (2010/02/07)
The present invention is directed to analogs of aminoglycoside compounds of the class having a glycosylated 2-deoxystreptamine (2-DOS) ring as well as their preparation and use as prophylactic or therapeutics against microbial infection. Compounds of the
Design and synthesis of paromomycin-related heterocycle-substituted aminoglycoside mimetics based on a mass spectrometry RNA-binding assay
Ding, Yili,Hofstadler, Steven A.,Swayze, Eric E.,Risen, Lisa,Griffey, Richard H.
, p. 3409 - 3412 (2007/10/03)
A good starting point for the design of potent bactericidal compounds is the aminoglycoside paromomycin (1). The A-ring (shown in red) was replaced with a range of heterocycles. An ESIMS-based RNA-binding assay was used to screen the binding affinities of
An efficient synthesis of mimetics of neamine for RNA recognition.
Ding,Hofstadler,Swayze,Griffey
, p. 1621 - 1623 (2007/10/03)
As mimetics of neamine, several 4-heterocyclic 2-deoxystreptamine derivatives were chemically synthesized for RNA recognition. Conversion of 4-methylthiomethyl-5,6-di-O-acetyl-diazido-2-deoxystreptamine to the 4-chloromethyl derivative followed by reactions with different nuclophilic reagents gave the 4-heterocyclic 2-deoxystreptamine derivatives in satisfactory yields.