609342-47-4Relevant academic research and scientific papers
An efficient synthesis of mimetics of neamine for RNA recognition.
Ding,Hofstadler,Swayze,Griffey
, p. 1621 - 1623 (2001)
As mimetics of neamine, several 4-heterocyclic 2-deoxystreptamine derivatives were chemically synthesized for RNA recognition. Conversion of 4-methylthiomethyl-5,6-di-O-acetyl-diazido-2-deoxystreptamine to the 4-chloromethyl derivative followed by reactions with different nuclophilic reagents gave the 4-heterocyclic 2-deoxystreptamine derivatives in satisfactory yields.
Design and synthesis of paromomycin-related heterocycle-substituted aminoglycoside mimetics based on a mass spectrometry RNA-binding assay
Ding, Yili,Hofstadler, Steven A.,Swayze, Eric E.,Risen, Lisa,Griffey, Richard H.
, p. 3409 - 3412 (2007/10/03)
A good starting point for the design of potent bactericidal compounds is the aminoglycoside paromomycin (1). The A-ring (shown in red) was replaced with a range of heterocycles. An ESIMS-based RNA-binding assay was used to screen the binding affinities of
