609342-82-7Relevant academic research and scientific papers
Design and synthesis of paromomycin-related heterocycle-substituted aminoglycoside mimetics based on a mass spectrometry RNA-binding assay
Ding, Yili,Hofstadler, Steven A.,Swayze, Eric E.,Risen, Lisa,Griffey, Richard H.
, p. 3409 - 3412 (2007/10/03)
A good starting point for the design of potent bactericidal compounds is the aminoglycoside paromomycin (1). The A-ring (shown in red) was replaced with a range of heterocycles. An ESIMS-based RNA-binding assay was used to screen the binding affinities of
Efficient Synthesis of Heterocyclic 2-Deoxysteptamine Derivatives as RNA Binding Ligands
Ding, Yili,Hofstadler, Steven A.,Swayze, Eric E.,Griffey, Richard H.
, p. 908 - 909 (2007/10/03)
An efficient strategy for the synthesis of heterocyclic 2-deoxystreptamine derivatives is described. The resulting compounds showed good RNA binding affinities from ESI-MS RNA binding assay.
